ArticleWorld journal of gastroenterology2010
Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation.The Journal of biological chemistry · 2013Trial
- SLIT2 as a key regulator and therapeutic target in liver injury.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Deciphering the Role of Oroxylin A in Liver Fibrosis.Drug design, development and therapy · 2025Review
- Modulation of hepatic stellate cells by MutaflorJournal of translational medicine · 2022Article
- 3D-printed dermis-specific extracellular matrix mitigates scar contraction via inducing early angiogenesis and macrophage M2 polarization.Bioactive materials · 2022Article
- Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis.Pharmaceutical biology · 2021Article
- Puerarin alleviates liver fibrosis via inhibition of the ERK1/2 signaling pathway in thioacetamide-induced hepatic fibrosis in rats.Experimental and therapeutic medicine · 2019Article
- JAK-STAT signalling and the atrial fibrillation promoting fibrotic substrate.Cardiovascular research · 2017Article
- The Role of Embryonic Stem Cell-expressed RAS (ERAS) in the Maintenance of Quiescent Hepatic Stellate Cells.The Journal of biological chemistry · 2016Article
- [Reversal of liver fibrosis through AG490 inhibitor-mediated inhibition of the TGFbeta1-STAT3 pathway].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2015Article
- Overexpression of pim-3 and protective role in lipopolysaccharide-stimulated hepatic stellate cells.World journal of gastroenterology · 2015Article
- Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Epigenetic Changes during Hepatic Stellate Cell Activation.PloS one · 2015Article
- The regulatory roles of microRNA-146b-5p and its target platelet-derived growth factor receptor α (PDGFRA) in erythropoiesis and megakaryocytopoiesis.The Journal of biological chemistry · 2014Article
- Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis.Hepatology (Baltimore, Md.) · 2014Article
- Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle.Frontiers in aging neuroscience · 2014Review
- The HIV matrix protein p17 promotes the activation of human hepatic stellate cells through interactions with CXCR2 and Syndecan-2.PloS one · 2014Article
- Kinin-B2 receptor activity determines the differentiation fate of neural stem cells.The Journal of biological chemistry · 2012Article
- Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis.Hepatology (Baltimore, Md.) · 2012Article
- Cytokines and STATs in Liver Fibrosis.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
aimTo identify signaling pathways and genes that initiate and commit hepatic stellate cells (HSCs) to transdifferentiation.
methodsPrimary HSCs were isolated from male Sprague-Dawley rats and cultured on plastic for 0-10 d. Gene expression was assessed daily (quiescent to day 10 culture-activation) by real time polymerase chain reaction and data clustered using AMADA software. The significance of JAK/STAT signaling to HSC transdifferentiation was determined by treating cells with a JAK2 inhibitor.
resultsGenetic cluster analyses, based on expression of these 21 genes, showed similar expression profiles on days 1-3, days 5 and 6, and days 7-10, while freshly isolated cells (day Q) and day 4 cells were genotypically distinct from any of the other days. Additionally, gene expression clustering revealed strong upregulation of interleukin-6, JAK2 and STAT3 mRNA in the early stages of activation. Inhibition of the JAK/STAT signaling pathway impeded the morphological transdifferentiation of HSCs which correlated with decreased mRNA expression of several profibrotic genes including collagens, α-SMA, PDGFR and TGFβR.
conclusionThese data demonstrate unique clustered genetic profiles during the daily progression of HSC transdifferentiation and that JAK/STAT signaling may be critical in the early stages of transdifferentiation.
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