ArticleInternational journal of hematology2010
Aggressive sporadic histiocytic sarcoma with immunoglobulin heavy chain gene rearrangement and t(14;18).
Article in International journal of hematology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Histiocytic Sarcoma: A Review and Update.International journal of molecular sciences · 2025Review
- Genomic profiling of primary histiocytic sarcoma reveals two molecular subgroups.Haematologica · 2020Article
- Rare myeloid sarcoma with KMT2A (MLL)-ELL fusion presenting as a vaginal wall mass.Diagnostic pathology · 2019Article
- Rosai-Dorfman Disease Harboring an Activating KRAS K117N Missense Mutation.Head and neck pathology · 2016Article
- Canine Histiocytic Malignancies-Challenges and Opportunities.Veterinary sciences · 2016Review
- Primary splenic histiocytic sarcoma complicated with prolonged idiopathic thrombocytopenia and secondary bone marrow involvement: a unique surgical case presenting with splenomegaly but non-nodular lesions.Diagnostic pathology · 2012Article
- Imaging features of primary extranodal histiocytic sarcoma: report of two cases and a review of the literature.Cancer imaging : the official publication of the International Cancer Imaging Society · 2012Review
- Cytogenetics findings in a histiocytic sarcoma case.Case reports in hematology · 2012Article
- Metastatic Histiocytic Sarcoma with Secondary Involvement of the Skin: A Case Report.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histiocytic sarcoma (HS) is a rare but aggressive malignant neoplasm of histiocytic lineage with a poor prognosis. Immunohistochemically, the neoplastic cells are positive for CD163, CD68, and lysozyme, and negative for B and T cell markers. However, molecular studies on the origin of the neoplastic cells remain inconclusive. A 54-year-old woman was admitted to our hospital because of painful swelling of the left knee. Examination revealed generalized lymphadenopathy and splenomegaly. HS was diagnosed according to morphologic and immunohistochemical features observed on biopsy of the left inguinal lymph node. The tumor demonstrated a clonal immunoglobulin heavy chain gene rearrangement and a clonal cytogenetic abnormality including t(14;18) which was confirmed by fluorescence in situ hybridization analysis showing the IgH/BCL2 fusion gene. The neoplastic cells were negative for PAX5, a B cell associated transcription factor, and positive for CEBPβ, a transcription factor mediating macrophage and myeloid differentiation. Positron emission tomography showed disseminated areas of increased 18F-fluorodeoxyglucose uptake in multiple lymph nodes, the liver, spleen, both lungs, both kidneys, and many bony sites. The patient received localized irradiation therapy followed by chemotherapy, she failed to respond and died of the disease progression. The case findings suggest lineage promiscuity or plasticity related to the pathogenesis of HS.
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