ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2011
Epithelial remodeling and claudin mRNA abundance in the gill and kidney of puffer fish (Tetraodon biocellatus) acclimated to altered environmental ion levels.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Structural Adaptations to Saline Stress: Histomorphological Changes in the Osmoregulatory and Metabolic Organs ofBiology · 2025Article
- Expression levels and activities of energy-yielding ATPases in the oligohaline neritid snail Theodoxus fluviatilis under changing environmental salinities.Biology open · 2022Article
- Mitogenome analysis of dwarf pufferfish (Journal of genetics · 2019Article
- Thermal acclimation mitigates cold-induced paracellular leak from the Drosophila gut.Scientific reports · 2017Article
- FXYD8, a Novel Regulator of Renal NaFrontiers in physiology · 2017Article
- Dietary salt loading and ion-poor water exposure provide insight into the molecular physiology of the rainbow trout gill epithelium tight junction complex.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- The response of claudin-like transmembrane septate junction proteins to altered environmental ion levels in the larval mosquito Aedes aegypti.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- Short-term Effects of Hypertonic Shock on NaZoological studies · 2016Article
- Article
- Claudins in teleost fishes.Tissue barriers · 2013Review
- A role for tricellulin in the regulation of gill epithelium permeability.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Claudins and the modulation of tight junction permeability.Physiological reviews · 2013Review
- The tight junction protein claudin-b regulates epithelial permeability and sodium handling in larval zebrafish, Danio rerio.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Evidence for a role of tight junctions in regulating sodium permeability in zebrafish (Danio rerio) acclimated to ion-poor water.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In water of varying ion content, the gills and kidney of fishes contribute significantly to the maintenance of salt and water balance. However, little is known about the molecular architecture of the tight junction (TJ) complex and the regulation of paracellular permeability characteristics in these tissues. In the current studies, puffer fish (Tetraodon biocellatus) were acclimated to freshwater (FW), seawater (SW) or ion-poor freshwater (IPW) conditions. Following acclimation, alterations in systemic endpoints of hydromineral status were examined in conjunction with changes in gill and kidney epithelia morphology/morphometrics, as well as claudin TJ protein mRNA abundance. T. biocellatus were able to maintain endpoints of hydromineral status within relatively tight limits across the broad range of water ion content examined. Both gill and kidney tissue exhibited substantial alterations in morphology as well as claudin TJ protein mRNA abundance. These responses were particularly pronounced when comparing fish acclimated to SW versus those acclimated to IPW. TEM observations of IPW-acclimated fish gills revealed the presence of cells that exhibited the typical characteristics of gill mitochondria-rich cells (e.g. voluminous, Na(+)-K(+)-ATPase-immunoreactive, exposed to the external environment at the apical surface), but were not mitochondria-rich. To our knowledge, this type of cell has not previously been described in hyperosmoregulating fish gills. Furthermore, modifications in the morphometrics and claudin mRNA abundance of kidney tissue support the notion that spatial alterations in claudin TJ proteins along the nephron of fishes will likely play an important role in the regulation of salt and water balance in these organisms.
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