ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2011
The preventive effects of pulsed electromagnetic fields on diabetic bone loss in streptozotocin-treated rats.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 71 citations in OpenAlex.
- The effects and mechanisms of electromagnetic fields on bone remodeling: From clinical to laboratory.Journal of orthopaedic translation · 2025Review
- Early protection against bone stress injuries by mobilization of endogenous targeted bone remodeling.iScience · 2023Article
- Pulsed electromagnetic fields inhibit mandibular bone deterioration depending on the Wnt3a/β-catenin signaling activation in type 2 diabetic db/db mice.Scientific reports · 2022Article
- Review
- Protective effects of low-magnitude high-frequency vibration on high glucose-induced osteoblast dysfunction and bone loss in diabetic rats.Journal of orthopaedic surgery and research · 2021Article
- Translational Insights into Extremely Low Frequency Pulsed Electromagnetic Fields (ELF-PEMFs) for Bone Regeneration after Trauma and Orthopedic Surgery.Journal of clinical medicine · 2019Review
- Pulsed electromagnetic fields: promising treatment for osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Review
- Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell.American journal of translational research · 2018Review
- Effects of low-intensity pulsed electromagnetic fields on bone microarchitecture, mechanical strength and bone turnover in type 2 diabetic db/db mice.Scientific reports · 2017Article
- Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-Stem cells international · 2017Article
- Pulsed electromagnetic fields promote osteogenesis and osseointegration of porous titanium implants in bone defect repair through a Wnt/β-catenin signaling-associated mechanism.Scientific reports · 2016Article
- Effects of extremely low frequency pulsed magnetic fields on diabetic nephropathy in streptozotocin-treated rats.Biomedical engineering online · 2016Article
- Effect of Pulsed Electromagnetic Field on Bone Formation and Lipid Metabolism of Glucocorticoid-Induced Osteoporosis Rats through Canonical Wnt Signaling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Photobiomodulation and bone healing in diabetic rats: evaluation of bone response using a tibial defect experimental model.Lasers in medical science · 2015Article
- Chronic Exposure to Static Magnetic Fields from Magnetic Resonance Imaging Devices Deserves Screening for Osteoporosis and Vitamin D Levels: A Rat Model.International journal of environmental research and public health · 2015Article
- Pulsed electromagnetic fields inhibit bone loss in streptozotocin-induced diabetic rats.Endocrine · 2015Article
- Pentoxifylline and electromagnetic field improved bone fracture healing in rats.Drug design, development and therapy · 2015Article
- Moderate-intensity rotating magnetic fields do not affect bone quality and bone remodeling in hindlimb suspended rats.PloS one · 2014Article
- MiR-378 overexpression attenuates high glucose-suppressed osteogenic differentiation through targeting CASP3 and activating PI3K/Akt signaling pathway.International journal of clinical and experimental pathology · 2014Article
- Evaluation of stability of surface-treated mini-implants in diabetic rabbits.International journal of dentistry · 2014Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe present study was the first report demonstrating that pulsed electromagnetic field (PEMF) could partially prevent bone strength and architecture deterioration and improve the impaired bone formation in streptozotocin-induced diabetic rats. The findings indicated that PEMF might become a potential additive method for inhibiting diabetic osteopenia or osteoporosis.
introductionDiabetes mellitus (DM) can cause various musculoskeletal abnormalities. Optimal therapeutic methods for diabetic bone complication are still lacking. It is essential to develop more effective and safe therapeutic methods for diabetic bone disorders. Pulsed electromagnetic field (PEMF) as an alternative noninvasive method has proven to be effective for treating fracture healing and osteoporosis in non-diabetic conditions. However, the issue about the therapeutic effects of PEMF on diabetic bone complication has not been previously investigated.
methodsWe herein systematically evaluated the preventive effects of PEMF on diabetic bone loss in streptozotocin-treated rats. Two similar experiments were conducted. In each experiment, 16 diabetic and eight non-diabetic rats were equally assigned to the control, DM, and DM + PEMF group. DM + PEMF group was subjected to daily 8-h PEMF exposure for 8 weeks.
resultsIn experiment 1, three-point bending test suggested that PEMF improved the biomechanical quality of diabetic bone tissues, evidenced by increased maximum load, stiffness, and energy absorption. Microcomputed tomography analysis demonstrated that DM-induced bone architecture deterioration was partially reversed by PEMF, evidenced by increased Tb.N, Tb.Th, BV/TV, and Conn.D and reduced Tb.Sp and SMI. Serum OC analysis indicated that PEMF partially prevented DM-induced decrease in bone formation. In experiment 2, no significant difference in the bone resorption marker TRACP5b was observed. These biochemical findings were further supported by the dynamic bone histomorphometric parameters BFR/BS and Oc.N/BS.
conclusionsThe results demonstrated that PEMF could partially prevent DM-induced bone strength and architecture deterioration and improve the impaired bone formation. PEMF might become a potential additive method for inhibiting diabetic osteoporosis.
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