ArticlePloS one2010
Impact of drug stock-outs on death and retention to care among HIV-infected patients on combination antiretroviral therapy in Abidjan, Côte d'Ivoire.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 4 of them syntheses that pooled it.
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Who cites it
73 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Tracking health commodity inventory and notifying stock levels via mobile devices: a mixed methods systematic review.The Cochrane database of systematic reviews · 2020Pooled it
- Supply kits for antenatal and childbirth care: a systematic review.Reproductive health · 2017Pooled it
- Trends in CD4 count at presentation to care and treatment initiation in sub-Saharan Africa, 2002-2013: a meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Pooled it
- Quantifying and addressing losses along the continuum of care for people living with HIV infection in sub-Saharan Africa: a systematic review.Journal of the International AIDS Society · 2012Pooled it
- Optimizing drug inventory management with a web-based information system: The TBTC Study 31/ACTG A5349 experience.Contemporary clinical trials · 2021Trial
- Trial
- Trial
- Drug stock-outs in HIV, tuberculosis, and malaria programs: a systematic review.EClinicalMedicine · 2026Review
- Applying convergent parallel mixed methods design to investigate medication adherence among people living with HIV in resource-limited settings: methodological insights from Ghana.Frontiers in public health · 2026Article
- Attrition and associated factors among patients on chronic antihypertensive therapy at Mulago hospital, Uganda: A mixed method study.PloS one · 2026Article
- Availability of essential medicines, inventory management practices, and related challenges in internally displaced persons (IDP) camps, eastern Amhara, Ethiopia: an explanatory sequential mixed study.Conflict and health · 2025Article
- Malaria prophylaxis stock-outs and birth- and maternal outcomes in Zimbabwe.BMC public health · 2025Article
- A Cross-Sectional Client Satisfaction Study Among Persons Living with HIV Attending a Large HIV Treatment Centre in Trinidad.Healthcare (Basel, Switzerland) · 2025Article
- Experience in Diagnostic of HIV Drug Resistance in the Mekong Delta Region, Vietnam: A Comparative Analysis Before and After the COVID-19 Pandemic.Diagnostics (Basel, Switzerland) · 2025Article
- Promising Practices in Capacity Development for Health Supply Chains in Resource-Constrained Countries.Global health, science and practice · 2025Review
- Challenges and the Way Forward in Demand-Forecasting Practices within the Ethiopian Public Pharmaceutical Supply Chain.Pharmacy (Basel, Switzerland) · 2024Article
- Antiretroviral therapy regimen modification rates and associated factors in a cohort of HIV/AIDS patients in Asmara, Eritrea: a 16-year retrospective analysis.Scientific reports · 2023Article
- Virological non-suppression among adult males attending HIV care services in the fishing communities in Bulisa district, Uganda.PloS one · 2023Article
- Antiretroviral treatment interruption and resumption within 16 weeks among HIV-positive adults in Jinan, China: a retrospective cohort study.Frontiers in public health · 2023Article
- HIV/AIDS services quality in health centers of East Shoa zone, Oromia, Ethiopia.African health sciences · 2022Article
13 more citing papers are in PubMed but not listed here.
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11 authors.
Funding
Abstract
backgroundTo evaluate the type and frequency of antiretroviral drug stock-outs, and their impact on death and interruption in care among HIV-infected patients in Abidjan, Côte d'Ivoire. METHODS AND
findingsWe conducted a cohort study of patients who initiated combination antiretroviral therapy (cART) in three adult HIV clinics between February 1, 2006 and June 1, 2007. Follow-up ended on February 1, 2008. The primary outcome was cART regimen modification, defined as at least one drug substitution, or discontinuation for at least one month due to drug stock-outs at the clinic pharmacy. The secondary outcome for patients who were on cART for at least six months was interruption in care, or death. A Cox regression model with time-dependent variables was used to assess the impact of antiretroviral drug stock-outs on interruption in care or death. Overall, 1,554 adults initiated cART and were followed for a mean of 13.2 months. During this time, 72 patients discontinued treatment and 98 modified their regimen because of drug stock-outs. Stock-outs involved nevirapine and fixed-dose combination zidovudine/lamivudine in 27% and 51% of cases. Of 1,554 patients, 839 (54%) initiated cART with fixed-dose stavudine/lamivudine/nevirapine and did not face stock-outs during the study period. Among the 975 patients who were on cART for at least six months, stock-out-related cART discontinuations increased the risk of interruption in care or death (adjusted hazard ratio [HR], 2.83; 95%CI, 1.25-6.44) but cART modifications did not (adjusted HR, 1.21; 95%CI, 0.46-3.16).
conclusionscART stock-outs affected at least 11% of population on treatment. Treatment discontinuations due to stock-outs were frequent and doubled the risk of interruption in care or death. These stock-outs did not involve the most common first-line regimen. As access to cART continues to increase in sub-Saharan Africa, first-line regimens should be standardized to decrease the probability of drug stock-outs.
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