ArticlePloS one2010
Human endometrial CD98 is essential for blastocyst adhesion.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- Genome-Wide CRISPR/Cas9 Screening Identifies the COMMANDER Recycling Complex as a Key Player in EV Uptake.Journal of extracellular vesicles · 2025Article
- Differential innate immune response of endometrial cells to porcine reproductive and respiratory syndrome virus type 1 versus type 2.PloS one · 2023Article
- Three-dimensional microengineered vascularised endometrium-on-a-chip.Human reproduction (Oxford, England) · 2021Article
- Immunotherapy using IgE or CAR T cells for cancers expressing the tumor antigen SLC3A2.Journal for immunotherapy of cancer · 2021Article
- Tetraspanins, More than Markers of Extracellular Vesicles in Reproduction.International journal of molecular sciences · 2020Review
- Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems.International journal of molecular sciences · 2020Review
- Molecular Signaling Regulating Endometrium-Blastocyst Crosstalk.International journal of molecular sciences · 2019Review
- Clomiphene citrate impairs the endometrial CD98 expression in ovariectomized and non-ovariectomized rats: Role of HCG.International journal of reproductive biomedicine · 2019Article
- A Review of Mechanisms of Implantation.Development & reproduction · 2017Review
- Absence of CD9 reduces endometrial VEGF secretion and impairs uterine repair after parturition.Scientific reports · 2014Article
- Biomarkers in reproductive medicine: the promise, and can it be fulfilled?Fertility and sterility · 2013Review
- Endometrial exosomes/microvesicles in the uterine microenvironment: a new paradigm for embryo-endometrial cross talk at implantation.PloS one · 2013Article
- Homeostatic and innate immune responses: role of the transmembrane glycoprotein CD98.Cellular and molecular life sciences : CMLS · 2012Review
- Substrate-attached materials are enriched with tetraspanins and are analogous to the structures associated with rear-end retraction in migrating cells.Cell adhesion & migrationArticle
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnderstanding the molecular basis of embryonic implantation is of great clinical and biological relevance. Little is currently known about the adhesion receptors that determine endometrial receptivity for embryonic implantation in humans. METHODS AND PRINCIPAL
findingsUsing two human endometrial cell lines characterized by low and high receptivity, we identified the membrane receptor CD98 as a novel molecule selectively and significantly associated with the receptive phenotype. In human endometrial samples, CD98 was the only molecule studied whose expression was restricted to the implantation window in human endometrial tissue. CD98 expression was restricted to the apical surface and included in tetraspanin-enriched microdomains of primary endometrial epithelial cells, as demonstrated by the biochemical association between CD98 and tetraspanin CD9. CD98 expression was induced in vitro by treatment of primary endometrial epithelial cells with human chorionic gonadotropin, 17-β-estradiol, LIF or EGF. Endometrial overexpression of CD98 or tetraspanin CD9 greatly enhanced mouse blastocyst adhesion, while their siRNA-mediated depletion reduced the blastocyst adhesion rate.
conclusionsThese results indicate that CD98, a component of tetraspanin-enriched microdomains, appears to be an important determinant of human endometrial receptivity during the implantation window.
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