ArticleInternational journal of inflammation2010
A Strong Impact of Genetic Background on Gut Microflora in Mice.
Article in International journal of inflammation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability.Nutrients · 2022Review
- Exploring the impact of intestinal ion transport on the gut microbiota.Computational and structural biotechnology journal · 2021Review
- Role of the microbiota in ileitis of a mouse model of inflammatory bowel disease-Glutathione peroxide isoenzymes 1 and 2-double knockout mice on a C57BL background.MicrobiologyOpen · 2020Article
- Development but not diet alters microbial communities in the Neotropical arboreal trap jaw ant Daceton armigerum: an exploratory study.Scientific reports · 2020Article
- Variation in gut bacterial composition is associated with Haemonchus contortus parasite infection of sheep.Animal microbiome · 2020Article
- Dexamethasone and Tofacitinib suppress NADPH oxidase expression and alleviate very-early-onset ileocolitis in mice deficient in GSH peroxidase 1 and 2.Life sciences · 2019Article
- The Use of Defined Microbial Communities To Model Host-Microbe Interactions in the Human Gut.Microbiology and molecular biology reviews : MMBR · 2019Review
- Selective colonization ability of human fecal microbes in different mouse gut environments.The ISME journal · 2019Article
- Selenoproteins in colon cancer.Free radical biology & medicine · 2018Review
- Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium.Redox biology · 2017Article
- Intestinal microbiota: a potential target for the treatment of postmenopausal osteoporosis.Bone research · 2017Review
- Extracellular Signal-Regulated Kinase Signaling in CD4-Expressing Cells Inhibits Osteochondromas.Frontiers in immunology · 2017Article
- NADPH oxidase-1 deficiency offers little protection inWorld journal of gastroenterology · 2016Article
- The Gut-Brain Axis, BDNF, NMDA and CNS Disorders.Neurochemical research · 2016Review
- Piglet nasal microbiota at weaning may influence the development of Glässer's disease during the rearing period.BMC genomics · 2016Article
- Exploring Relationships between Host Genome and Microbiome: New Insights from Genome-Wide Association Studies.Frontiers in microbiology · 2016Review
- Induction of bacterial antigen-specific colitis by a simplified human microbiota consortium in gnotobiotic interleukin-10-/- mice.Infection and immunity · 2014Article
- Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2.Free radical biology & medicine · 2014Article
- Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene.Free radical biology & medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Genetic background affects susceptibility to ileocolitis in mice deficient in two intracellular glutathione peroxidases, GPx1 and GPx2. The C57BL/6 (B6) GPx1/2 double-knockout (DKO) mice have mild ileocolitis, and 129S1/Sv (129) DKO mice have severe inflammation. We used diet to modulate ileocolitis; a casein-based defined diet with AIN76A micronutrients (AIN) attenuates inflammation compared to conventional LabDiets. Because luminal microbiota induce DKO ileocolitis, we assessed bacterial composition with automated ribosomal intergenic-spacer analysis (ARISA) on cecal DNA. We found that mouse strain had the strongest impact on the composition of microbiota than diet and GPx genotypes. In comparing AIN and LabDiet, DKO mice were more resistant to change than the non-DKO or WT mice. However, supplementing yeast and inulin to AIN diet greatly altered microflora profiles in the DKO mice. From 129 DKO strictly, we found overgrowth of Escherichia coli. We conclude that genetic background predisposes mice to colonization of potentially pathogenic E. coli.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.