ArticleBioinformation2009
LCK, survivin and PI-3K in the molecular biomarker profiling of oral lichen planus and oral squamous cell carcinoma.
Article in Bioinformation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Significance of immunohistochemistry biomarkers in prediction of malignant transformation of oral lichen planus: A systematic review.Medicina oral, patologia oral y cirugia bucal · 2022Pooled it
- A systematic review of proteomic biomarkers in oral squamous cell cancer.World journal of surgical oncology · 2021Pooled it
- Connecting the dots: investigating the link between environmental, genetic, and epigenetic influences in metabolomic alterations in oral squamous cell carcinoma.Journal of experimental & clinical cancer research : CR · 2024Review
- Review
- Toward a fractalomic idiotype/anti-idiotypic paradigm.Bioinformation · 2022Article
- Immunohistochemical evaluation of survivin in oral lichen planus and oral squamous cell carcinoma - a retrospective study.Medicine and pharmacy reports · 2021Article
- Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper.Medicina oral, patologia oral y cirugia bucal · 2021Review
- Expression of Survivin in Oral Potentially Malignant Disorders: An Immunohistochemical Study.Journal of pharmacy & bioallied sciences · 2020Article
- Article
- Epigenomic dysregulation-mediated alterations of key biological pathways and tumor immune evasion are hallmarks of gingivo-buccal oral cancer.Clinical epigenetics · 2019Article
- Histopathological features of oral lichen planus and its response to corticosteroid therapy: A retrospective study.Medicine · 2019Article
- Oral lichenoid lesions: distinguishing the benign from the deadly.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Review
- Evolution of dental informatics as a major research tool in oral pathology.Journal of oral and maxillofacial pathology : JOMFP · 2012Article
- Proteomic signature of periodontal disease in pregnancy: Predictive validity for adverse outcomes.Bioinformation · 2011Article
- The role of the microenvironment in tumor immune surveillance.Bioinformation · 2011Article
- Proteomics as it pertains to oral pathologies and dental research.Bioinformation · 2011Article
- Survivin expression in oral lichen planus: Role in malignant transformation.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cell signaling is critical in oral lichen planus (OLP) based on the pathogenesis of this chronic inflammatory autoimmune mucocutaneous lesion. Lck plays a key role in T cell signaling; ultimately this signaling affects other targets such as PI-3K. Excessive activity in PI-3K inhibits apoptosis and promotes uncontrolled cell growth. Molecular biomarker profiling in OLP, Chronic Interface Mucosities (CIM), Epithelial Dysplasia (EpD) and Oral Squamous Cell Carcinoma (SCCA) with application of the principle of biomarker voting may represent a new frontier in the diagnosis, assessment and the arguable debate of OLP transformation to cancer. The presence of Lck, PI-3K and Survivin, a cancer specific anti-apoptotic protein was assessed, using immunohistochemistry and tissue micro-array on patient samples, in OLP, SCCA, CIM and EpD. Lck expression was very high in 78.6 % of OLP patients compared to 3.7% in SCCA; PI-3K was high in 63% of SCCA, 100% of EpD, and 35.7% OLP cases. Survivin was high in 64.3% of OLP cases, 96.3% of SCCA, and 100% of EpD. CIM cases may be slightly different molecularly to OLP. Taken together, our data suggest that biomarker protein voting can be effectively used to isolate high-risk OLP cases. Specifically, we show data with four remarkable cases demonstrating that molecular factors are predictive of histopathology. We conclude that it is safer to treat OLP as premalignant lesions, to adopt aggressive treatment measure in histopathologic described well and moderately differentiated SCCA, and to monitor progress of these diseases molecularly using individualized auto-proteomic approach. The use of Lck inhibitors in OLP management needs to be investigated in the future.
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Registered trials
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