ArticlePloS one2010
Nutritional programming in the rat is linked to long-lasting changes in nutrient sensing and energy homeostasis in the hypothalamus.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 79 citations in OpenAlex.
- Undernutrition-related diabetes in mice is linked to early undernutrition.American journal of physiology. Endocrinology and metabolism · 2026Article
- Unveiling the long-term impact: exploring the link between exposure to the great Chinese famine and health-related quality of life in middle-aged and elderly populations through propensity score matching.BMC public health · 2025Article
- Unraveling the Molecular Mechanisms of the Neurodevelopmental Consequences of Fetal Protein Deficiency: Insights From Rodent Models and Public Health Implications.Biological psychiatry global open science · 2024Review
- Comparative Analysis of the GH/IGF-1 Axis during the First Sixth Months in Children with Low Birth Weight.Children (Basel, Switzerland) · 2023Article
- Maternal Protein Restriction in Rats Alters Postnatal Growth and Brain Lipid Sensing in Female Offspring.Nutrients · 2023Article
- Impact of prenatal famine exposure on adulthood fasting blood glucose level.Scientific reports · 2022Article
- Protein restriction during lactation causes transgenerational metabolic dysfunction in adult rat offspring.Frontiers in nutrition · 2022Article
- Are Brain and Cognitive Reserve Shaped by Early Life Circumstances?Frontiers in neuroscience · 2022Review
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- Liver disease in obesity and underweight: the two sides of the coin. A narrative review.Eating and weight disorders : EWD · 2021Review
- Famine exposure in early life is associated with visceral adipose dysfunction in adult females.European journal of nutrition · 2019Article
- The effect of Chinese famine exposure in early life on dietary patterns and chronic diseases of adults.Public health nutrition · 2019Article
- The association between fetal-stage exposure to the China famine and risk of diabetes mellitus in adulthood: results from the China health and retirement longitudinal study.BMC public health · 2018Article
- Mapping Molecular Datasets Back to the Brain Regions They are Extracted from: Remembering the Native Countries of Hypothalamic Expatriates and Refugees.Advances in neurobiology · 2018Article
- Article
- Exposure to severe famine in the prenatal or postnatal period and the development of diabetes in adulthood: an observational study.Diabetologia · 2017Observational
- DNA methylation regulates hypothalamic gene expression linking parental diet during pregnancy to the offspring's risk of obesity in Psammomys obesus.International journal of obesity (2005) · 2016Article
- Molecular pathways associated with the nutritional programming of plant-based diet acceptance in rainbow trout following an early feeding exposure.BMC genomics · 2016Article
- Is Exposure to Famine in Childhood and Economic Development in Adulthood Associated With Diabetes?The Journal of clinical endocrinology and metabolism · 2015Article
- Maternal obesity programs offspring non-alcoholic fatty liver disease through disruption of 24-h rhythms in mice.International journal of obesity (2005) · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNutrient deficiency during perinatal development is associated with an increased risk to develop obesity, diabetes and hypertension in the adulthood. However, the molecular mechanisms underlying the developmental programming of the metabolic syndrome remain largely unknown. METHODOLOGY/PRINCIPAL
findingsGiven the essential role of the hypothalamus in the integration of nutritional, endocrine and neuronal cues, here we have analyzed the profile of the hypothalamus transcriptome in 180 days-old rats born to dams fed either a control (200 g/kg) or a low-protein (80 g/kg) diet through pregnancy and lactation. From a total of 26 209 examined genes, 688 were up-regulated and 309 down-regulated (P<0.003) by early protein restriction. Further bioinformatic analysis of the data revealed that perinatal protein restriction permanently alters the expression of two gene clusters regulating common cellular processes. The first one includes several gate keeper genes regulating insulin signaling and nutrient sensing. The second cluster encompasses a functional network of nuclear receptors and co-regulators of transcription involved in the detection and use of lipid nutrients as fuel which, in addition, link temporal and nutritional cues to metabolism through their tight interaction with the circadian clock. CONCLUSIONS/SIGNIFICANCE: Collectively, these results indicate that the programming of the hypothalamic circuits regulating energy homeostasis is a key step in the development of obesity associated with malnutrition in early life and provide a valuable resource for further investigating the role of the hypothalamus in the programming of the metabolic syndrome.
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