ArticlePsychiatry (Edgmont (Pa. : Township))2006
An Evidence-Based Approach to Augmentation and Combination Strategies for: Treatment-Resistant Depression.
Article in Psychiatry (Edgmont (Pa. : Township)), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pharmacologic management of chronic neuropathic pain: Review of the Canadian Pain Society consensus statement.Canadian family physician Medecin de famille canadien · 2017Pooled it
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- Low doses of ketamine and guanosine abrogate corticosterone-induced anxiety-related behavior, but not disturbances in the hippocampal NLRP3 inflammasome pathway.Psychopharmacology · 2021Article
- Can pharmacotherapy improve treatment outcomes in people with co-occurring major depressive and cocaine use disorders?Expert opinion on pharmacotherapy · 2021Review
- Neuroendocrine Assessment of Dopaminergic Function during Antidepressant Treatment in Major Depressed Patients.Brain sciences · 2021Article
- Defining polypharmacy: in search of a more comprehensive determination method applied in a tertiary psychiatric hospital.Therapeutic advances in psychopharmacology · 2021Article
- Computational Analysis of Therapeutic Neuroadaptation to Chronic Antidepressant in a Model of the Monoaminergic Neurotransmitter and Stress Hormone Systems.Frontiers in pharmacology · 2019Article
- Vilazodone for the treatment of major depressive disorder: focusing on its clinical studies and mechanism of action.Psychiatry investigation · 2015Review
- Clinical utility of vilazodone for the treatment of adults with major depressive disorder and theoretical implications for future clinical use.Neuropsychiatric disease and treatment · 2012Article
- Vilazodone: a brief pharmacological and clinical review of the novel serotonin partial agonist and reuptake inhibitor.Therapeutic advances in psychopharmacology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DESIGN, SETTING,
participantsThis paper is a review article that collects and synthesizes up-to-date information about the practice of augmenting and combining medications in regards to treatment resistant major depressive disorder. The authors have written the paper in an evidence-based model in order to show the reader where adequate data exists in regards to these strategies. A thorough MEDLINE search was utilized to collect many papers dedicated to this area of study spanning 1989-2005. MEASUREMENTS: Papers were divided based upon drug intervention and scientific merit, where randomized controlled trials were given the most evidence-based weight and case studies the least.
resultsThe literature review data is divided into augmentation and combination strategies in descending order of scientific stringency. For augmentation, lithium, antipsychotic, and thyroid addition has the most empirical support. For combination strategies, heterocyclic addition is the best studied.
conclusionThere is much literature regarding complex medication management of major depression that is generally supportive of this practice. However, much of the literature contains underpowered and uncontrolled studies.
Indexed as
Identifiers
20975817PMC2958866What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.