ArticleNature communications2010
Divergent transcriptional activities determine limb identity.
Article in Nature communications, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- An integrated reference atlas of human skeletal muscle.EBioMedicine · 2026Article
- A simple model reveals why complex evolutionary innovations follow predictable paths.bioRxiv : the preprint server for biology · 2025Article
- Review
- Case report: A novelFrontiers in genetics · 2022Article
- Parallel Genetic Origin of Foot Feathering in Birds.Molecular biology and evolution · 2020Article
- Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder.Human molecular genetics · 2018Article
- Anti-apoptotic effects of IGF-I on mortality and dysmorphogenesis in tbx5-deficient zebrafish embryos.BMC developmental biology · 2018Article
- PITX1 promotes chondrogenesis and myogenesis in mouse hindlimbs through conserved regulatory targets.Developmental biology · 2018Article
- Similarity of morphological composition and developmental patterning in paired fins of the elephant shark.Scientific reports · 2017Article
- Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells.Scientific reports · 2017Article
- Genome-wide use of high- and low-affinity Tbrain transcription factor binding sites during echinoderm development.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Limb development: a paradigm of gene regulation.Nature reviews. Genetics · 2017Review
- Loss of scleraxis in mice leads to geometric and structural changes in cortical bone, as well as asymmetry in fracture healing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Transcriptomic signatures shaped by cell proportions shed light on comparative developmental biology.Genome biology · 2017Article
- Pitx1 determines characteristic hindlimb morphologies in cartilage micromass culture.PloS one · 2017Article
- Endothelial cell specification in the somite is compromised in Pax3-positive progenitors of Foxc1/2 conditional mutants, with loss of forelimb myogenesis.Development (Cambridge, England) · 2016Article
- Genetic basis of hindlimb loss in a naturally occurring vertebrate model.Biology open · 2016Article
- The T-box gene family: emerging roles in development, stem cells and cancer.Development (Cambridge, England) · 2014Review
- Tbx4 interacts with the short stature homeobox gene Shox2 in limb development.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Pitx1 broadly associates with limb enhancers and is enriched on hindlimb cis-regulatory elements.Developmental biology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Limbs develop using a common genetic programme despite widely differing morphologies. This programme is modulated by limb-restricted regulators such as hindlimb (HL) transcription factors Pitx1 and Tbx4 and the forelimb (FL) Tbx5. Both Tbx factors have been implicated in limb patterning and growth, but their relative activities and underlying mechanisms remain unclear. In this paper, we show that Tbx4 and Tbx5 harbour conserved and divergent transcriptional regulatory domains that account for their roles in limb development. In particular, both factors share an activator domain and the ability to stimulate limb growth. However, we find that Tbx4 is the primary effector of HL identity for both skeletal and muscle development; this activity relies on a repressor domain that is inactivated by a human TBX4 small-patella syndrome mutation. We propose that limb identity is largely achieved by default in FL, whereas a specific repressor activity unique to Tbx4 determines HL identity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.