ReviewObesity facts2010
Chipping away the 'missing heritability': GIANT steps forward in the molecular elucidation of obesity - but still lots to go.
Review in Obesity facts, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gene set of nuclear-encoded mitochondrial regulators is enriched for common inherited variation in obesity.PloS one · 2013Pooled it
- Discovery of phenotypic networks from genotypic association studies with application to obesity.International journal of data mining and bioinformatics · 2015Trial
- Role of Increasing Body Mass Index in Gut Barrier Dysfunction, Systemic Inflammation, and Metabolic Dysregulation in Obesity.Nutrients · 2024Article
- Weight reduction interventions for the management of atrial fibrillation in overweight and obese people.The Cochrane database of systematic reviews · 2024Review
- BMI and Cardiometabolic Traits in Japanese: A Mendelian Randomization Study.Journal of epidemiology · 2024Article
- Interaction between genetic susceptibility to obesity and food intake on BMI in Finnish school-aged children.Scientific reports · 2023Article
- The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits.Nature reviews. Endocrinology · 2022Review
- Effect of interaction between obesity-promoting genetic variants and behavioral factors on the risk of obese phenotypes.Molecular genetics and genomics : MGG · 2021Article
- The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals.Genes · 2020Review
- Dietary patterns interact with the variations of 18q21.23 rs17782313 locus on regulation of hypothalamic-pituitary axis hormones and cardio-metabolic risk factors in obesity.Eating and weight disorders : EWD · 2020Article
- The Effect Sizes ofGenes · 2020Article
- Genome-wide association study of morbid obesity in Han Chinese.BMC genetics · 2019Article
- Body composition: population epidemiology and concordance in Australian children aged 11-12 years and their parents.BMJ open · 2019Article
- Obesity: global epidemiology and pathogenesis.Nature reviews. Endocrinology · 2019Review
- Increased adiposity, inflammation, metabolic disruption and dyslipidemia in adult male offspring of DOSS treated C57BL/6 dams.Scientific reports · 2019Article
- MC4R variant rs17782313 and manifestation of obese phenotype in Pakistani females.RSC advances · 2018Article
- Impact of the Polymorphism NearJournal of human kinetics · 2017Article
- Genetics of body fat mass and related traits in a pig population selected for leanness.Scientific reports · 2017Article
- Genome-wide association study of body mass index in subjects with alcohol dependence.Addiction biology · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although heritability of human body weight is assumed to be high, only a small fraction of the variance can as yet be attributed to molecular genetic factors. Single monogenic forms of obesity have been identified. Functionally relevant coding mutations in the melanocortin-4 receptor gene occur in 1-6% of extremely obese children and adolescents and thus represent the most common major gene effect. Genome-wide association studies (GWAS) had previously identified 14 obesity loci with genome-wide significant (p < 5 x 10-8) associations. Many of the respective genes are expressed in the central nervous system. The GIANT (Genetic Investigation of ANtropometric Traits) Consortium has now performed a meta-analysis of GWAS data based on 123,865 individuals of European ancestry followed by confirmatory analyses for the 42 best independent loci in up to 125,931 independent individuals (Speliotes et al: Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index. Nature Genetics; epub October 2010 [1]). Apart from confirming the 14 known loci, 18 novel BMI-associated loci (p < 5 x 10-8) were identified. Several of the new loci point to genes involved in key hypothalamic pathways of energy balance. The identified variants mostly have small to very small effect sizes; only 1-2% of the BMI variance is explained. Currently, a consensus explanation for this 'missing heritability' in complex diseases has not yet emerged.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.