ArticleExperimental biology and medicine (Maywood, N.J.)2010
Relationship between brachial and femoral artery endothelial vasomotor function/phenotype in pigs.
Article in Experimental biology and medicine (Maywood, N.J.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Exercise training and vascular cell phenotype in a swine model of familial hypercholesterolaemia: conduit arteries and veins.Experimental physiology · 2014Article
- Gene expression differences during the heterogeneous progression of peripheral atherosclerosis in familial hypercholesterolemic swine.BMC genomics · 2013Article
- The NO donor sodium nitroprusside: evaluation of skeletal muscle vascular and metabolic dysfunction.Microvascular research · 2013Article
- Relationship between upper and lower limb conduit artery vasodilator function in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In humans, the measurement of brachial artery endothelial vasomotor function is used as a surrogate index of systemic endothelial health; however, the applicability of brachial artery findings to other vasculatures needs to be examined. The purpose of the present investigation was to test the following hypotheses: (1) brachial and femoral artery endothelium-dependent/independent relaxation is correlated; (2) endothelial expression of pro-/antiatherogenic proteins is correlated between brachial and femoral arteries; and (3) within vessel, there is a positive correlation between expression of antiatherogenic proteins and endothelium-dependent/independent relaxation, and an inverse correlation between expression of proatherogenic proteins and relaxation. In vitro endothelium-dependent (bradykinin [BK] and acetylcholine [Ach]) and -independent (sodium nitroprusside [SNP]) relaxation were evaluated in harvested brachial and femoral arteries of 96 Yucatan miniature swine. In a subset of pigs (n = 32), expression of 18 pro-/antiatherogenic proteins was measured from brachial and femoral artery endothelial cell scrapes using immunoblot analysis. Vascular sensitivity (half-maximal effective dose) to BK, Ach and SNP was highly correlated between brachial and femoral arteries (P < 0.01). A significant correlation was found between brachial and femoral arteries for content of six of the 18 measured proteins (P < 0.01). Furthermore, expression of two proteins (eNOS and COX-1) was correlated with vasorelaxation function in the brachial artery (P < 0.01). We provide the first evidence of a relationship between brachial and femoral artery endothelium-dependent relaxation. Our data also suggest that, in general terms, endothelial expression of several established pro-/antiatherogenic proteins is not robustly associated between brachial and femoral arteries, and does not link strongly to vasorelaxation function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.