ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Critical role of IL-25 in nematode infection-induced alterations in intestinal function.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 105 citations in OpenAlex.
- Serum nuclear alarmins associate with IgE-mediated food sensitization, but have no role in effector response to food challenge.Pediatric research · 2026Article
- IL-25 Enhances Eosinophil-Associated Inflammation in Angiostrongylus cantonensis-Infected Mice.Parasite immunology · 2026Article
- Aging impairs type 2 immune responses to nematodes associated with reduced gut microbiota responsiveness.Scientific reports · 2025Article
- Genomic Regions Associated with Resistance to Gastrointestinal Nematode Parasites in Sheep-A Review.Genes · 2024Review
- Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Changes in resident microbiota associated with mice susceptibility or resistance to the intestinal trematodeParasitology · 2022Article
- The Role of Inflammatory Mediators in the Development of Gastrointestinal Motility Disorders.International journal of molecular sciences · 2022Review
- "Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity".Mucosal immunology · 2022Review
- Interleukin 25 and its biological features and function in intestinal diseases.Central-European journal of immunology · 2022Review
- IL25 Enhanced Colitis-Associated Tumorigenesis in Mice by Upregulating Transcription Factor GLI1.Frontiers in immunology · 2022Article
- Cytokine elevation in the mouse small intestine at the early stage of infection with the gastrointestinal parasite Heligmosomoides polygyrus.The Journal of veterinary medical science · 2021Article
- IL-25 Treatment Improves Metabolic Syndrome in High-Fat Diet and Genetic Models of Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses.Parasites & vectors · 2020Article
- Maternal diesel particle exposure promotes offspring asthma through NK cell-derived granzyme B.The Journal of clinical investigation · 2020Article
- The Construction and Immunoadjuvant Activities of the Oral Interleukin-17B Expressed byVaccines · 2020Article
- ncRNAs in Type-2 Immunity.Non-coding RNA · 2020Review
- Immunity to Soil-Transmitted Helminths: Evidence From the Field and Laboratory Models.Frontiers in immunology · 2020Review
- Innate Immune Responses Associated with Resistance againstJournal of immunology research · 2019Article
- Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion.eLife · 2018Article
- Immunity to gastrointestinal nematode infections.Mucosal immunology · 2018Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
IL-25 (IL-17E) is a member of the IL-17 cytokine family. IL-25-deficient mice exhibit impaired Th2 immunity against nematode infection, implicating IL-25 as a key component in mucosal immunity. The sources of IL-25 and mechanisms responsible for the induction of Th2 immunity by IL-25 in the gastrointestinal tract remain poorly understood. There is also little information on the regulation of IL-25 during inflammation or its role in gut function. In the current study, we investigated the regulation of IL-25 during Nippostrongylus brasiliensis infection and the contribution of IL-25 to the infection-induced alterations in intestinal function. We found that epithelial cells, but not immune cells, are the major source of IL-25 in the small intestine. N. brasiliensis infection-induced upregulation of IL-25 depends upon IL-13 activation of STAT6. IL-25(-/-) mice had diminished intestinal smooth muscle and epithelial responses to N. brasiliensis infection that were associated with an impaired Th2 protective immunity. Exogenous IL-25 induced characteristic changes similar to those after nematode infection but was unable to restore the impaired host immunity against N. brasiliensis infection in IL-13(-/-) mice. These data show that IL-25 plays a critical role in nematode infection-induced alterations in intestinal function that are important for host protective immunity, and IL-13 is the major downstream Th2 cytokine responsible for the IL-25 effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.