ArticleProceedings of the National Academy of Sciences of the United States of America2010
Joint linkage-linkage disequilibrium mapping is a powerful approach to detecting quantitative trait loci underlying drought tolerance in maize.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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102 citing papers in PubMed, 231 citations in OpenAlex.
- Multienvironment multilocus association mapping reveals genomic regions for drought-related traits in tropical maize.G3 (Bethesda, Md.) · 2026Article
- A new plant SUMO ligase, MPEL1, synergizes with MAPK16 to regulate resistance against Fusarium pathogens.The EMBO journal · 2026Article
- Haplotype-based genome-wide association study uncovers QTL for fruit-related traits in the 287 tomato accessions.BMC plant biology · 2026Article
- Identification of candidate genes for heat tolerance in rice by genome-wide association study and transcriptome sequencing.BMC plant biology · 2026Article
- Exploring the potential of naked barley to manage deoxynivalenol accumulation from Fusarium head blight.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- MAGIC populations: a next-generation framework for dissecting complex quantitative traits and accelerating molecular breeding in crops.Frontiers in plant science · 2026Review
- Comprehensive analysis of genomic loci associated with glaucousness in wheat (Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Genome-wide association mapping and genomic prediction analyses reveal the genetic architecture of grain yield and agronomic traits under drought and optimum conditions in maize.BMC plant biology · 2025Article
- Beyond the genome: the role of functional markers in contemporary plant breeding.Frontiers in plant science · 2025Review
- Combined Genome-Wide Association Study and Linkage Analysis for Mining Candidate Genes for the Kernel Row Number in Maize (Plants (Basel, Switzerland) · 2024Article
- Genomic basis determining root system architecture in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- ZmADF5, a Maize Actin-Depolymerizing Factor Conferring Enhanced Drought Tolerance in Maize.Plants (Basel, Switzerland) · 2024Article
- QTL mapping for flowering time in a maize-teosinte population under well-watered and water-stressed conditions.Molecular breeding : new strategies in plant improvement · 2023Article
- Genome-Wide Association Mapping of QTL Underlying Groat Protein Content of a Diverse Panel of Oat Accessions.International journal of molecular sciences · 2023Article
- Genome-wide association study as a powerful tool for dissecting competitive traits in legumes.Frontiers in plant science · 2023Review
- An Integration of Linkage Mapping and GWAS Reveals the Key Genes for Ear Shank Length in Maize.International journal of molecular sciences · 2022Article
- Linkage Mapping Reveals QTL for Flowering Time-Related Traits under Multiple Abiotic Stress Conditions in Maize.International journal of molecular sciences · 2022Article
- Meta-QTL analysis and candidate genes identification for various abiotic stresses in maize (Molecular breeding : new strategies in plant improvement · 2022Article
- Dissection of Maize Drought Tolerance at the Flowering Stage Using Genome-Wide Association Studies.Genes · 2022Article
- The Genetic Architecture of Juvenile Growth Traits in the ConiferFrontiers in plant science · 2022Article
42 more citing papers are in PubMed but not listed here.
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11 authors at 4 institutions in 3 countries.
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Abstract
This paper describes two joint linkage-linkage disequilibrium (LD) mapping approaches: parallel mapping (independent linkage and LD analysis) and integrated mapping (datasets analyzed in combination). These approaches were achieved using 2,052 single nucleotide polymorphism (SNP) markers, including 659 SNPs developed from drought-response candidate genes, screened across three recombinant inbred line (RIL) populations and 305 diverse inbred lines, with anthesis-silking interval (ASI), an important trait for maize drought tolerance, as the target trait. Mapping efficiency was improved significantly due to increased population size and allele diversity and balanced allele frequencies. Integrated mapping identified 18 additional quantitative trait loci (QTL) not detected by parallel mapping. The use of haplotypes improved mapping efficiency, with the sum of phenotypic variation explained (PVE) increasing from 5.4% to 23.3% for single SNP-based analysis. Integrated mapping with haplotype further improved the mapping efficiency, and the most significant QTL had a PVE of up to 34.7%. Normal allele frequencies for 113 of 277 (40.8%) SNPs with minor allele frequency (<5%) in 305 lines were recovered in three RIL populations, three of which were significantly associated with ASI. The candidate genes identified by two significant haplotype loci included one for a SET domain protein involved in the control of flowering time and the other encoding aldo/keto reductase associated with detoxification pathways that contribute to cellular damage due to environmental stress. Joint linkage-LD mapping is a powerful approach for detecting QTL underlying complex traits, including drought tolerance.
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