Evidence map›Paper›PMID 20974748›Full record

ReviewSchizophrenia bulletin2011

The prevention of schizophrenia--what can we learn from eco-epidemiology?

James B Kirkbride, Peter B Jones

Abstract readReview
In one paragraph

Review in Schizophrenia bulletin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  5. Review
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  7. Article
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  9. Article
  10. Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study.The Journal of nervous and mental disease · 2015
    Article
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  12. Article
  13. Review
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  16. Review
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  18. Review
  19. Article
  20. Urbanicity, social adversity and psychosis.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

James B KirkbrideDepartment of Psychiatry, Herchel Smith Building for Brain and Mind Sciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, UK.
Peter B Jones

Funding

Department of Health RP-PG-0606-1335Wellcome Trust WT085540
6 · The paper itself

Abstract

The search for the causes of schizophrenia has predominantly originated from 2 research paradigms; genetics and epidemiology. While each approach has made important contributions to etiological understanding, neither has fully resolved the exact milieu of risk factors for schizophrenia, and there is growing recognition that several pathways to the onset of such disorders may exist. Eco-epidemiology offers an integrative framework to study schizophrenia etiology, incorporating multiple, interactive levels of causation, including genetic, epigenetic, individual, familial, community, and societal domains over the life course. In this article, we review the current evidence base, through the lens of eco-epidemiology, to determine whether it warrants the design and implementation of putative prevention strategies for schizophrenia. We argue that while there are potentially large public health gains available, we do not currently have sufficient empirical data to design effective prevention strategies. It will be important for the research community to more fully elucidate the likely multifactorial, multilevel, polygenetic, and eco-epidemiological basis of schizophrenia before we can design useful prevention strategies. We conclude by speculating on the forms effective strategies might take.

Indexed as

Schizophrenic PsychologySocial EnvironmentCausalityComorbidityCross-Sectional StudiesEmigrants and ImmigrantsEpigenesis, GeneticGenotypeHumansLife Change EventsPsychosocial DeprivationRisk FactorsSchizophreniaSocioeconomic Factors

Identifiers

PMID20974748
PMCPMC3044619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.