Evidence map›Paper›PMID 20974747›Full record

ArticleSchizophrenia bulletin2011

Prevention and schizophrenia--the role of dietary factors.

John McGrath, Alan Brown, David St Clair

Abstract read
In one paragraph

Article in Schizophrenia bulletin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Abundant pleiotropy in human complex diseases and traits.American journal of human genetics · 2011
    Pooled it
  3. Trial
  4. Trial
  5. Synergistic pathways to psychosis: understanding developmental risk and resilience factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Stress, Environment and Early Psychosis.Current neuropharmacology · 2024
    Review
  10. Brain Iron Homeostasis and Mental Disorders.Antioxidants (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Developmental Manipulation-Induced Changes in Cognitive Functioning.Current topics in behavioral neurosciences · 2023
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

John McGrathQueensland Centre for Mental Health Research, The Park Centre for Mental Health,Wacol, Australia. john_mcgrath@qcmhr.uq.edu
Alan Brown
David St Clair
New York State Psychiatric InstitutePark Centre for Mental Health · AUUniversity of Aberdeen · GB

Funding

Epidemiology of Prenatal Factors and Adult PsychopathologyK02MH065422 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BROWN, ALAN STEWART · 2003 to 2012
$1.2M
NIMH NIH HHS K02MH065422-06
6 · The paper itself

Abstract

Adequate prenatal nutrition is essential for optimal brain development. There is a growing body of evidence from epidemiology linking exposure to nutritional deprivation and increased risk of schizophrenia. Based on studies from the Netherlands and China, those exposed to macronutrient deficiencies during famine have an increased risk of schizophrenia. With respect to micronutrients, we focus on 3 candidates where there is biological plausibility for a role in this disorder and at least 1 study of an association with schizophrenia. These nutrients include vitamin D, folic acid, and iron. While the current evidence is incomplete, we discuss the potential implications of these findings for the prevention of schizophrenia. We argue that schizophrenia can draw inspiration from public health interventions related to prenatal nutrition and other outcomes and speculate on relevant factors that bear on the nature, risks, impact, and logistics of various nutritional strategies that may be employed to prevent this disorder.

Indexed as

Aged, 80 and overAnemia, Iron-DeficiencyCausalityCross-Sectional StudiesDeveloping CountriesFemaleFolic Acid DeficiencyHumansIncidenceInfant, NewbornMalnutritionPregnancyRisk FactorsSchizophreniaStarvationVitamin D Deficiency

Identifiers

PMID20974747
PMCPMC3044637
OpenAlexW2166626895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.