ArticleCellular immunology2011
Chronic alcohol consumption decreases the percentage and number of NK cells in the peripheral lymph nodes and exacerbates B16BL6 melanoma metastasis into the draining lymph nodes.
Article in Cellular immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Alcohol consumption and cancer progression: Mechanistic insights, immune dysregulation, and public health implications.Translational oncology · 2026Review
- Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Natural killer cell effector function is critical for host defense against alcohol-associated bacterial pneumonia.NPJ biofilms and microbiomes · 2024Article
- Competing endogenous RNA network characterization of lymph node metastases in Leuran gastric cancer subtypes.Journal of cancer research and clinical oncology · 2023Article
- Regulation of Natural Killer Cell TGF-β and AhR Signaling Pathways Via the Intestinal Microbiota is Critical for Host Defense Against Alcohol-Associated Bacterial Pneumonia.Research square · 2023Article
- Ethanol Metabolism and Melanoma.Cancers · 2023Review
- Alcohol remodels the immunosuppressive tumor microenvironment by targeting myeloid-derived suppressor cells.American journal of cancer research · 2023Article
- Review
- Analysis of mRNA expression differences in bladder cancer metastasis based on TCGA datasets.The Journal of international medical research · 2021Article
- Possible Immunotherapeutic Strategies Based on Carcinogen-Dependent Subgroup Classification for Oral Cancer.Frontiers in molecular biosciences · 2021Review
- Essential Role of IFN-γ in Regulating Gut Antimicrobial Peptides and Microbiota to Protect Against Alcohol-Induced Bacterial Translocation and Hepatic Inflammation in Mice.Frontiers in physiology · 2020Article
- Chronic alcohol consumption inhibits peripheral NK cell development and maturation by decreasing the availability of IL-15.Journal of leukocyte biology · 2017Article
- The immunomodulatory, antitumor and antimetastatic responses of melanoma-bearing normal and alcoholic mice to sunitinib and ALT-803: a combinatorial treatment approach.Cancer immunology, immunotherapy : CII · 2016Article
- Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival.Alcohol research : current reviews · 2015Review
- Therapeutic effect of daphnetin on the autoimmune arthritis through demethylation of proapoptotic genes in synovial cells.Journal of translational medicine · 2014Article
- Chronic ethanol feeding induces subset loss and hyporesponsiveness in skin T cells.Alcoholism, clinical and experimental research · 2014Article
- Significant differences in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients.Clinics (Sao Paulo, Brazil) · 2013Observational
- Chronic alcohol consumption impairs distribution and compromises circulation of B cells in B16BL6 melanoma-bearing mice.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The epigenetics of autoimmunity.Cellular & molecular immunology · 2011Review
- Decoding melanoma metastasis.Cancers · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
NK cells in the lymph nodes play important roles in inhibiting tumor metastasis into draining lymph nodes. Previously, we reported that chronic alcohol consumption interferes with NK cell trafficking from the bone marrow to the spleen. Herein, we found that alcohol consumption decreases the numbers of NK cells in lymph nodes. Adoptive transfer experiments indicated that continued exposure of donor splenocytes to alcohol inhibits NK but not T cell trafficking to lymph nodes. Alcohol did not negatively affect CCR7(+) and CXCR3(+) NK cells, but decreased the percentage and number of CD62L(+) NK cells in the spleen, which are an important source of NK cell trafficking into the lymph nodes. These data suggest that modulation of the microenvironment associated with alcohol consumption impairs the trafficking of NK cells to lymph nodes. The decreased number of NK cells in the lymph nodes was associated with increased melanoma metastasis into the draining lymph nodes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.