ArticleBMC neuroscience2010
Slowing of axonal regeneration is correlated with increased axonal viscosity during aging.
Article in BMC neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Did axons evolve by activating cytokinesis during interphase? A hypothesis on the origin of neurons.Molecular biology of the cell · 2025Review
- Limitations to clinically restoring meaningful peripheral nerve function across gaps and overcoming them.Experimental biology and medicine (Maywood, N.J.) · 2025Review
- Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons.Aging cell · 2024Article
- A simple active fluid model unites cytokinesis, cell crawling, and axonal outgrowth.bioRxiv : the preprint server for biology · 2024Article
- A simple active fluid model unites cytokinesis, cell crawling, and axonal outgrowth.Frontiers in cell and developmental biology · 2024Article
- Ageing in the brain: mechanisms and rejuvenating strategies.Cellular and molecular life sciences : CMLS · 2023Review
- Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces.International journal of molecular sciences · 2020Article
- The Influence of Neuron-Extrinsic Factors and Aging on Injury Progression and Axonal Repair in the Central Nervous System.Frontiers in cell and developmental biology · 2020Review
- Crowd Control: Effects of Physical Crowding on Cargo Movement in Healthy and Diseased Neurons.Frontiers in cellular neuroscience · 2019Review
- The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms.Neuroscience letters · 2017Review
- Aging of cerebral white matter.Ageing research reviews · 2017Review
- Measurement of subcellular force generation in neurons.Biophysical journal · 2015Article
- Sensoric protection after median nerve injury: babysitter-procedure prevents muscular atrophy and improves neuronal recovery.BioMed research international · 2014Article
- Drosophila growth cones advance by forward translocation of the neuronal cytoskeletal meshwork in vivo.PloS one · 2013Article
- The emerging role of forces in axonal elongation.Progress in neurobiology · 2011Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs we age, the speed of axonal regeneration declines. At the biophysical level, why this occurs is not well understood.
resultsTo investigate we first measured the rate of axonal elongation of sensory neurons cultured from neonatal and adult rats. We found that neonatal axons grew 40% faster than adult axons (11.5 µm/hour vs. 8.2 µm/hour). To determine how the mechanical properties of axons change during maturation, we used force calibrated towing needles to measure the viscosity (stiffness) and strength of substrate adhesion of neonatal and adult sensory axons. We found no significant difference in the strength of adhesions, but did find that adult axons were 3 times intrinsically stiffer than neonatal axons.
conclusionsTaken together, our results suggest decreasing axonal stiffness may be part of an effective strategy to accelerate the regeneration of axons in the adult peripheral nervous system.
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Registered trials
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