ArticleBMC neuroscience2010
Transplanted bone marrow stem cells relocate to infarct penumbra and co-express endogenous proliferative and immature neuronal markers in a mouse model of ischemic cerebral stroke.
Article in BMC neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The Use of Stem Cells as a Potential Treatment Method for Selected Neurodegenerative Diseases: Review.Cellular and molecular neurobiology · 2023Review
- Wasp venom fromPharmaceutical biology · 2022Article
- Therapeutic effects of dental pulp stem cells on vascular dementia in rat models.Neural regeneration research · 2021Article
- Tanshinone IIA promotes the differentiation of bone marrow mesenchymal stem cells into neuronal-like cells in a spinal cord injury model.Journal of translational medicine · 2018Article
- Intravenous administration of DPSCs and BDNF improves neurological performance in rats with focal cerebral ischemia.International journal of molecular medicine · 2018Article
- Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis.EXCLI journal · 2016Article
- Heat shock pretreatment improves stem cell repair following ischemia-reperfusion injury via autophagy.World journal of gastroenterology · 2015Article
- Article
- Recovery of neurological function of ischemic stroke by application of conditioned medium of bone marrow mesenchymal stem cells derived from normal and cerebral ischemia rats.Journal of biomedical science · 2014Article
- Autologous bone marrow mononuclear cells in ischemic cerebrovascular accident paves way for neurorestoration: a case report.Case reports in medicine · 2014Article
- Experimental models of brain ischemia: a review of techniques, magnetic resonance imaging, and investigational cell-based therapies.Frontiers in neurology · 2014Review
- Granulocyte colony-stimulating factor increases the therapeutic efficacy of bone marrow mononuclear cell transplantation in cerebral ischemia in mice.BMC neuroscience · 2011Article
- Potential applications of germline cell-derived pluripotent stem cells in organ regeneration.OrganogenesisReview
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies demonstrate that neurogenesis may be induced or activated following vascular insults, which may be important for neuronal regeneration and functional recovery. Understanding the cellular mechanism underlying stroke-associated neurogenesis is of neurobiological as well as neurological/clinical relevance. The present study attempted to explore potential homing and early development of transplanted bone marrow stem cells in mouse forebrain after focal occlusion of the middle cerebral artery, an experimental model of ischemic stroke.
resultsBone marrow stem cells isolated from donor mice were confirmed by analysis of surface antigen profile, and were pre-labeled with a lipophilic fluorescent dye PKH26, and subsequently transfused into recipient mice with middle cerebral artery coagulation. A large number of PKH26-labeled cells were detected surrounding the infarct site, most of which colocalized with immunolabelings for the proliferating cell nuclear antigen (PCNA) and some also colocalized with the immature neuronal marker doublecortin (DCX) during 1-2 weeks after the bone marrow cells transfusion.
conclusionsThe present study shows that transplanted bone marrow cells largely relocate to the infarct penumbra in ischemic mouse cerebrum. These transplanted bone marrow cells appear to undergo a process of in situ proliferation and develop into putative cortical interneurons during the early phase of experimental vascular injury.
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