ArticleEnvironmental health : a global access science source2010
Subclinical responses in healthy cyclists briefly exposed to traffic-related air pollution: an intervention study.
Article in Environmental health : a global access science source, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 168 citations in OpenAlex.
- Effect of particulate matter air pollution on C-reactive protein: a review of epidemiologic studies.Reviews on environmental health · 2012Pooled it
- Particulate matter exposure and health impacts of urban cyclists: a randomized crossover study.Environmental health : a global access science source · 2018Trial
- Pulmonary challenge with carbon nanoparticles induces a dose-dependent increase in circulating leukocytes in healthy males.BMC pulmonary medicine · 2017Trial
- The impacts of traffic-related and woodsmoke particulate matter on measures of cardiovascular health: a HEPA filter intervention study.Occupational and environmental medicine · 2015Trial
- Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-related gastrointestinal adverse events.Journal of translational medicine · 2013Trial
- Traffic-related air pollution and acute changes in heart rate variability and respiratory function in urban cyclists.Environmental health perspectives · 2011Trial
- In-traffic air pollution exposure and CC16, blood coagulation, and inflammation markers in healthy adults.Environmental health perspectives · 2011Trial
- Extreme Weather Events, Air Pollution, and Cardiovascular Health: Mechanisms and Challenges.Reviews in cardiovascular medicine · 2026Review
- Air Pollution and Endurance Exercise: A Systematic Review of the Potential Effects on Cardiopulmonary Health.Life (Basel, Switzerland) · 2025Review
- The Association Between Air Pollution Exposure and White Blood Cell Counts: A Nationwide Cross-Sectional Survey in South Korea.Journal of clinical medicine · 2024Article
- Emerging concern on air pollution and health: Trade-off between air pollution exposure and physical activity.Eco-Environment & Health · 2024Article
- A Reusable Multiplayer Game for Promoting Active School Transport: Development Study.JMIR serious games · 2022Article
- Childhood adversity, prenatal depression, and maternal inflammation across pregnancy.Obstetric medicine · 2022Article
- Effects of lubricant-fuel mixing on particle emissions in a single cylinder direct injection spark ignition engine.Scientific reports · 2022Article
- Immune cell targeting nanoparticles: a review.Biomaterials research · 2021Review
- HSP70 as a biomarker of the thin threshold between benefit and injury due to physical exercise when exposed to air pollution.Cell stress & chaperones · 2021Review
- The Association of White Blood Cells and Air Pollutants-A Population-Based Study.International journal of environmental research and public health · 2021Observational
- Application of high-resolution metabolomics to identify biological pathways perturbed by traffic-related air pollution.Environmental research · 2021Article
- A machine learning-based model to estimate PM2.5 concentration levels in Delhi's atmosphere.Heliyon · 2020Article
- Respiratory Effects of Exposure to Traffic-Related Air Pollutants During Exercise.Frontiers in public health · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNumerous epidemiological studies have demonstrated adverse health effects of a sedentary life style, on the one hand, and of acute and chronic exposure to traffic-related air pollution, on the other. Because physical exercise augments the amount of inhaled pollutants, it is not clear whether cycling to work in a polluted urban environment should be encouraged or not. To address this conundrum we investigated if a bicycle journey along a busy commuting road would induce changes in biomarkers of pulmonary and systematic inflammation in a group of healthy subjects.
methods38 volunteers (mean age: 43 ± 8.6 years, 26% women) cycled for about 20 minutes in real traffic near a major bypass road (road test; mean UFP exposure: 28,867 particles per cm3) in Antwerp and in a laboratory with filtered air (clean room; mean UFP exposure: 496 particles per cm3). The exercise intensity (heart rate) and duration of cycling were similar for each volunteer in both experiments. Exhaled nitric oxide (NO), plasma interleukin-6 (IL-6), platelet function, Clara cell protein in serum and blood cell counts were measured before and 30 minutes after exercise.
resultsPercentage of blood neutrophils increased significantly more (p = 0.004) after exercise in the road test (3.9%; 95% CI: 1.5 to 6.2%; p = 0.003) than after exercise in the clean room (0.2%; 95% CI: -1.8 to 2.2%, p = 0.83). The pre/post-cycling changes in exhaled NO, plasma IL-6, platelet function, serum levels of Clara cell protein and number of total blood leukocytes did not differ significantly between the two scenarios.
conclusionsTraffic-related exposure to particles during exercise caused a small increase in the distribution of inflammatory blood cells in healthy subjects. The health significance of this isolated change is unclear.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.