Evidence map›Paper›PMID 20973551›Full record

ArticleJournal of natural products2010

Highly brominated antimicrobial metabolites from a marine Pseudoalteromonas sp.

Domonkos Fehér, Russell Barlow, Jesse McAtee, Thomas K Hemscheidt

Abstract read
In one paragraph

Article in Journal of natural products, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Polymer degrading marineBeilstein journal of organic chemistry · 2024
    Review
  5. Genomic diversity and ecological distribution of marineMarine life science & technology · 2023
    Article
  6. Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023
    Review
  7. Halogenated Pyrrolopyrimidines with Low MIC onAntibiotics (Basel, Switzerland) · 2022
    Article
  8. Review
  9. Marine Pyrrole Alkaloids.Marine drugs · 2021
    Review
  10. Bromoperoxidase ProducingMarine drugs · 2019
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Domonkos FehérDepartment of Chemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 96822, United States.
Russell Barlow
Jesse McAtee
Thomas K Hemscheidt

Funding

Research Project 1: Ciguatera-Dinoflagellate Nutrient Profile and EcologyP50ES012740 · NIEHS · UNIVERSITY OF HAWAII AT MANOA · PI HEMSCHEIDT, THOMAS · 2004 to 2008
$2.4M
NIEHS NIH HHS P50 ES012740
6 · The paper itself

Abstract

Extracts of a marine Pseudoalteromonas sp. (CMMED 290) isolated from the surface of a nudibranch collected in Kaneohe Bay, Oahu, displayed significant antimicrobial activity against methicillin-resistant Staphylococcus aureus. Bioassay-guided fractionation of the lipophilic extract led to the isolation and structure elucidation of two new highly brominated compounds, 2,3,5,7-tetrabromobenzofuro[3,2-b]pyrrole (1) and 4,4',6-tribromo-2,2'-biphenol (2). In addition, we have identified the known compounds pentabromopseudilin and bromophene. We describe the isolation and structure elucidation of the compounds 1 and 2 together with their antimicrobial activities against methicillin-resistant Staphylococcus aureus.

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsCandida albicansDrug Screening Assays, AntitumorEscherichia coliHumansHydrocarbons, BrominatedMarine BiologyMethicillin ResistanceMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular StructureNuclear Magnetic Resonance, BiomolecularPhenolsPseudoalteromonasPyrroles2,3,5,7-tetrabromobenzofuro(3,2-b)pyrrole4,4',6-tribromo-2,2'-biphenolAnti-Bacterial AgentsAntineoplastic AgentsHydrocarbons, BrominatedPhenolsPyrroles

Identifiers

PMID20973551
PMCPMC2993825

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.