Evidence map›Paper›PMID 20972813›Full record

ReviewCellular and molecular life sciences : CMLS2011

Genetics of photoreceptor degeneration and regeneration in zebrafish.

Susan E Brockerhoff, James M Fadool

Open access · hybridAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The BDNF/TrkB Neurotrophin System in the Sensory Organs of Zebrafish.International journal of molecular sciences · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Color Processing in Zebrafish Retina.Frontiers in cellular neuroscience · 2018
    Review
  15. Leveraging Zebrafish to Study Retinal Degenerations.Frontiers in cell and developmental biology · 2018
    Review
  16. Article
  17. Review
  18. Article
  19. Opportunities for CRISPR/Cas9 Gene Editing in Retinal Regeneration Research.Frontiers in cell and developmental biology · 2017
    Review
  20. Müller glial cell-dependent regeneration of the neural retina: An overview across vertebrate model systems.Developmental dynamics : an official publication of the American Association of Anatomists · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Susan E BrockerhoffDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA. sbrocker@uw.edu
James M Fadool
Florida State University · USSeattle University · US

Funding

Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI MAUREEN E NEITZ · 1985 to 2026
$23.5M
Photoreceptor degeneration and rescue in zebrafishR01EY018814 · NEI · UNIVERSITY OF WASHINGTON · PI BROCKERHOFF, SUSAN E · 2009 to 2012
$1.9M
Developing Models of Retinal and Eye DefectsR01EY017753 · NEI · FLORIDA STATE UNIVERSITY · PI FADOOL, JAMES M · 2006 to 2010
$1.6M
NEI NIH HHS EY017753NEI NIH HHS EY018814NEI NIH HHS P30 EY001730NEI NIH HHS R01 EY017753NEI NIH HHS R01 EY018814
6 · The paper itself

Abstract

Zebrafish are unique in that they provide a useful model system for studying two critically important problems in retinal neurobiology, the mechanisms responsible for triggering photoreceptor cell death and the innate stem cell-mediated regenerative response elicited by this death. In this review we highlight recent seminal findings in these two fields. We first focus on zebrafish as a model for studying photoreceptor degeneration. We summarize the genes currently known to cause photoreceptor degeneration, and we describe the phenotype of a few zebrafish mutants in detail, highlighting the usefulness of this model for studying this process. In the second section, we discuss the several different experimental paradigms that are available to study regeneration in the teleost retina. A model outlining the sequence of gene expression starting from the dedifferentiation of Müller glia to the formation of rod and cone precursors is presented.

Indexed as

RegenerationAnimalsGenesModels, AnimalPhotoreceptor CellsRetinaRetinal DegenerationZebrafish

Identifiers

PMID20972813
PMCPMC3029675
OpenAlexW1970092966

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.