ArticleCellular and molecular life sciences : CMLS2011
Amyloid β-induced FOXRED2 mediates neuronal cell death via inhibition of proteasome activity.
Article in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Accurate and noninvasive prostate cancer detection using plasma-derived extracellular vesicle RNA.FEBS open bio · 2026Article
- ISR Modulators in Neurological Diseases.Current neuropharmacology · 2025Review
- Article
- Knockdown of FOXRED2 restrains proliferation, invasion and migration of human melanoma cells.Heliyon · 2023Article
- Potential miRNA-gene interactions determining progression of various ATLL cancer subtypes after infection by HTLV-1 oncovirus.BMC medical genomics · 2023Article
- Autophagy induction by trehalose: Molecular mechanisms and therapeutic impacts.Journal of cellular physiology · 2018Review
- Trehalose Inhibits Protein Aggregation Caused by Transient Ischemic Insults Through Preservation of Proteasome Activity, Not via Induction of Autophagy.Molecular neurobiology · 2017Article
- Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular Damage.International journal of molecular sciences · 2015Review
- iRhom1 regulates proteasome activity via PAC1/2 under ER stress.Scientific reports · 2015Article
- Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer's disease.Cellular and molecular life sciences : CMLS · 2014Review
- Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy.Cellular and molecular life sciences : CMLS · 2013Review
- Disulfide bond formation in the mammalian endoplasmic reticulum.Cold Spring Harbor perspectives in biology · 2012Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteasome inhibition has been regarded as one of the mediators of Aβ neurotoxicity. In this study, we found that FOXRED2, a novel endoplasmic reticulum (ER) residential protein, is highly up-regulated by Aβ in rat cortical neurons and SH-SY5Y cells. Over-expression of FOXRED2 inhibits proteasome activity in the microsomal fractions containing ER and interferes with proteasome assembly, as evidenced by gel filtration and native gel electrophoresis analysis. In contrast, reduced expression of FOXRED2 rescues Aβ-induced inhibition of proteasome activity. FOXRED2 is an unstable protein with two degradation boxes and one KEN box, and its N-terminal oxidoreductase domain is required for proteasome inhibition. Ectopic expression of FOXRED2 induces ER stress-mediated cell death via caspase-12, which is inhibited by Salubrinal. Further, down-regulation of FOXRED2 expression attenuates Aβ-induced cell death and the ER stress response. These results suggest that up-regulated FOXRED2 inhibits proteasome activity by interfering with 26S proteasome assembly to contribute to Aβ neurotoxicity via an ER stress response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.