ArticleNature nanotechnology2010
Training a molecular automaton to play a game.
Article in Nature nanotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 192 citations in OpenAlex.
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- Erasable and Field Programmable DNA Circuits Based on Configurable Logic Blocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
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- A Chemically Fuelled Molecular Automaton Displaying Programmed Migration of ZnChemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Massively Parallel DNA Computing Based on Domino DNA Strand Displacement Logic Gates.ACS synthetic biology · 2022Article
- Catalyst-based biomolecular logic gates.Catalysts (Basel, Switzerland) · 2022Article
- Protease circuits for processing biological information.Nature communications · 2020Article
- Cancer diagnosis with DNA molecular computation.Nature nanotechnology · 2020Article
- Enzyme-Guided Selection and Cascaded Emergence of Nanostructured Constitutional Dynamic Networks.Nano letters · 2020Article
- From Microbial Communities to Distributed Computing Systems.Frontiers in bioengineering and biotechnology · 2020Review
- Synthetic immunity by remote control.Theranostics · 2020Review
- Triggered reversible substitution of adaptive constitutional dynamic networks dictates programmed catalytic functions.Science advances · 2019Article
- Enzymatic Weight Update Algorithm for DNA-Based Molecular Learning.Molecules (Basel, Switzerland) · 2019Article
- Solving mazes with single-molecule DNA navigators.Nature materials · 2019Article
- Population analysis to increase the robustness of molecular computational identification and its extension into the near-infrared for substantial numbers of small objects.Chemical science · 2019Article
- Scaling up molecular pattern recognition with DNA-based winner-take-all neural networks.Nature · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research at the interface between chemistry and cybernetics has led to reports of 'programmable molecules', but what does it mean to say 'we programmed a set of solution-phase molecules to do X'? A survey of recently implemented solution-phase circuitry indicates that this statement could be replaced with 'we pre-mixed a set of molecules to do X and functional subsets of X'. These hard-wired mixtures are then exposed to a set of molecular inputs, which can be interpreted as being keyed to human moves in a game, or as assertions of logical propositions. In nucleic acids-based systems, stemming from DNA computation, these inputs can be seen as generic oligonucleotides. Here, we report using reconfigurable nucleic acid catalyst-based units to build a multipurpose reprogrammable molecular automaton that goes beyond single-purpose 'hard-wired' molecular automata. The automaton covers all possible responses to two consecutive sets of four inputs (such as four first and four second moves for a generic set of trivial two-player two-move games). This is a model system for more general molecular field programmable gate array (FPGA)-like devices that can be programmed by example, which means that the operator need not have any knowledge of molecular computing methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.