ArticleNature2010
Support for a synaptic chain model of neuronal sequence generation.
Article in Nature, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers.
What it found
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Who cites it
214 citing papers in PubMed, 419 citations in OpenAlex.
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- Mechanisms that create a sequence of feeding-related behaviors in the molluskJournal of neurophysiology · 2026Article
- High-throughput assessment of vocal modulation following chemogenetic inhibition in songbirds.iScience · 2026Article
- Temperature robustness of the timing network within songbird premotor nucleus HVC.Journal of computational neuroscience · 2026Article
- Automated, stress-free, and precise measurement of songbird weight in neuroscience experiments.PloS one · 2026Article
- Conditions for replay of neuronal assemblies.PLoS computational biology · 2026Article
- Time, space, memory and brain-body rhythms.Nature reviews. Neuroscience · 2026Review
- Article
- Hippocampal sequences represent working memory and implicit timing.Cell reports · 2025Article
- Correctness is its own reward: bootstrapping error signals in self-guided reinforcement learning.bioRxiv : the preprint server for biology · 2025Article
- Introductory notes before zebra finch song have unique timing properties while sharing acoustic properties with song.bioRxiv : the preprint server for biology · 2025Article
- Partially Observable Markov Models Inferred Using Statistical Tests Reveal Context-Dependent Syllable Transitions in Bengalese Finch Songs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Differential behavioral engagement of inhibitory interneuron subtypes in the zebra finch brain.Neuron · 2025Article
- Electromechanical Regulation Underlying Protein Nanoparticle-Induced Osmotic Pressure in Neurotoxic Edema.International journal of nanomedicine · 2025Article
- Variable and slow-paced neural dynamics in HVC underlie plastic song production in juvenile zebra finches.BMC neuroscience · 2024Article
- Identification of movie encoding neurons enables movie recognition AI.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Discovering plasticity rules that organize and maintain neural circuits.bioRxiv : the preprint server for biology · 2024Article
154 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In songbirds, the remarkable temporal precision of song is generated by a sparse sequence of bursts in the premotor nucleus HVC. To distinguish between two possible classes of models of neural sequence generation, we carried out intracellular recordings of HVC neurons in singing zebra finches (Taeniopygia guttata). We found that the subthreshold membrane potential is characterized by a large, rapid depolarization 5-10 ms before burst onset, consistent with a synaptically connected chain of neurons in HVC. We found no evidence for the slow membrane potential modulation predicted by models in which burst timing is controlled by subthreshold dynamics. Furthermore, bursts ride on an underlying depolarization of ∼10-ms duration, probably the result of a regenerative calcium spike within HVC neurons that could facilitate the propagation of activity through a chain network with high temporal precision. Our results provide insight into the fundamental mechanisms by which neural circuits can generate complex sequential behaviours.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.