ArticleDiabetes2011
P-selectin glycoprotein ligand-1 deficiency is protective against obesity-related insulin resistance.
Article in Diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- The Impact of Bariatric Surgery on Obesity-Associated NETosis, Immune Modulation, and Cardiovascular Risk Reduction.Obesity surgery · 2026Review
- Association between triglyceride glucose index and deep vein thrombosis following total knee arthroplasty: a retrospective case-control study.BMC geriatrics · 2025Article
- PSGL-1, a Strategic Biomarker for Pathological Conditions in HIV Infection: A Hypothesis Review.Viruses · 2023Review
- Diabetes mellitus and diabetic nephropathy: a review of the literature on hemostatic changes in coagulation and thrombosis.Blood research · 2022Review
- P-Selectin Glycoprotein Ligand-1 Deficiency Protects Against Aortic Aneurysm Formation Induced by DOCA Plus Salt.Cardiovascular drugs and therapy · 2022Article
- Long-term Impact of Mini-Gastric Bypass on Inflammatory Cytokines in Cohort of Morbidly Obese Patients: a Prospective Study.Obesity surgery · 2020Article
- Postprandial activation of leukocyte-endothelium interaction by fatty acids in the visceral adipose tissue microcirculation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Hemostasis, endothelial stress, inflammation, and the metabolic syndrome.Seminars in immunopathology · 2018Review
- Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity.American journal of physiology. Endocrinology and metabolism · 2017Article
- Targeting P-selectin glycoprotein ligand-1/P-selectin interactions as a novel therapy for metabolic syndrome.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Effect of bariatric surgery on systemic and adipose tissue inflammation.Surgical endoscopy · 2016Article
- Tissue-Specific and Genetic Regulation of Insulin Sensitivity-Associated Transcripts in African Americans.The Journal of clinical endocrinology and metabolism · 2016Article
- Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo.Nature communications · 2015Article
- Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes.Molecular therapy. Nucleic acids · 2014Article
- Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-κB and endothelial inflammatory response.Carbohydrate polymers · 2014Article
- Clinical marker of platelet hyperreactivity in diabetes mellitus.Diabetes & metabolism journal · 2013Article
- The microcirculation in adipose tissue inflammation.Reviews in endocrine & metabolic disorders · 2013Review
- β3-Adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation.The Journal of biological chemistry · 2013Article
- P-selectin glycoprotein ligand-1: a cellular link between perivascular adipose inflammation and endothelial dysfunction.Diabetes · 2012Article
- Glycosphingolipid modification: structural diversity, functional and mechanistic integration of diabetes.Diabetes & metabolism journal · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAn inflammatory process is involved in the mechanism of obesity-related insulin resistance. Recent studies indicate that monocyte chemoattractant protein-1 (MCP-1) is a major chemokine that promotes monocyte infiltration into adipose tissues; however, the adhesion pathway in adipose tissues remains unclear. We aimed to clarify the adhesion molecules that mediate monocyte infiltration into adipose tissue. RESEARCH DESIGN AND
methodsWe used a DNA microarray to compare the gene expression profiles in epididymal white adipose tissues (eWAT) between db/db mice and C57/BL6 mice each fed a high-fat diet (HFD) or a low-fat diet (LFD). We investigated the change of insulin resistance and inflammation in eWAT in P-selectin glycoprotein ligand-1 (PSGL-1) homozygous knockout (PSGL-1⁻(/)⁻) mice compared with wild-type (WT) mice fed HFD.
resultsDNA microarray analysis revealed that PSGL-1, a major ligand for selectins, is upregulated in eWAT from both db/db mice and WT mice fed HFD. Quantitative real-time RT-PCR and immunohistochemistry showed that PSGL-1 is expressed on both endothelial cells and macrophages in eWAT of obese mice. PSGL-1⁻(/)⁻ mice fed HFD showed a remarkable reduction of macrophage accumulation and expression of proinflammatory genes, including MCP-1 in eWAT. Moreover, adipocyte hypertrophy, insulin resistance, lipid metabolism, and hepatic fatty change were improved in PSGL-1⁻(/) ⁻mice compared with WT mice fed HFD.
conclusionsThese results indicate that PSGL-1 is a crucial adhesion molecule for the recruitment of monocytes into adipose tissues in obese mice, making it a candidate for a novel therapeutic target for the prevention of obesity-related insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.