ArticleJournal of bacteriology2011
Regulation and function of Escherichia coli sugar efflux transporter A (SetA) during glucose-phosphate stress.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Intracellular microbial shifts during COVID-19 infection and longitudinal recovery revealed by single-cell RNA sequencing.iScience · 2026Article
- The transcription factor Vca0578 (DsvR) mediated expression of ZapC is required to promote cell division during lytic transglycosylase insufficiency inbioRxiv : the preprint server for biology · 2026Article
- Article
- Lysis of Escherichia coli by colicin Ib contributes to bacterial cross-feeding by releasing active β-galactosidase.The ISME journal · 2025Article
- Article
- Determinants of target prioritization and regulatory hierarchy for the bacterial small RNA SgrS.Molecular microbiology · 2019Article
- Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method.Science advances · 2019Article
- Regulation of Transcription Termination of Small RNAs and by Small RNAs: Molecular Mechanisms and Biological Functions.Frontiers in cellular and infection microbiology · 2019Review
- Stringent Response Regulators Contribute to Recovery from Glucose Phosphate Stress in Escherichia coli.Applied and environmental microbiology · 2017Article
- Mycobacterium tuberculosis Major Facilitator Superfamily Transporters.The Journal of membrane biology · 2017Review
- Diverse mechanisms of post-transcriptional repression by the small RNA regulator of glucose-phosphate stress.Molecular microbiology · 2016Article
- Induction of the Sugar-Phosphate Stress Response Allows Saccharomyces cerevisiae 2-Methyl-4-Amino-5-Hydroxymethylpyrimidine Phosphate Synthase To Function in Salmonella enterica.Journal of bacteriology · 2015Article
- Insights into transcription termination of Hfq-binding sRNAs of Escherichia coli and characterization of readthrough products.RNA (New York, N.Y.) · 2015Article
- How do base-pairing small RNAs evolve?FEMS microbiology reviews · 2015Review
- The small RNA SgrS: roles in metabolism and pathogenesis of enteric bacteria.Frontiers in cellular and infection microbiology · 2014Review
- Physiological consequences of multiple-target regulation by the small RNA SgrS in Escherichia coli.Journal of bacteriology · 2013Article
- Depletion of glycolytic intermediates plays a key role in glucose-phosphate stress in Escherichia coli.Journal of bacteriology · 2013Article
- Genetic determinants for n-butanol tolerance in evolved Escherichia coli mutants: cross adaptation and antagonistic pleiotropy between n-butanol and other stressors.Applied and environmental microbiology · 2013Article
- Article
- Induction of the Pho regulon suppresses the growth defect of an Escherichia coli sgrS mutant, connecting phosphate metabolism to the glucose-phosphate stress response.Journal of bacteriology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulation of certain nonmetabolizable sugar-phosphates (including α-methyl glucoside-6-phosphate) in Escherichia coli is growth inhibitory and elicits the glucose-phosphate stress response. The transcription factor SgrR activates transcription of the small RNA SgrS under stress conditions. SgrS represses translation of mRNAs encoding sugar transporters. The sgrR and sgrS genes are located directly upstream of setA, and this gene organization is conserved in numerous enteric species, prompting the hypothesis that SetA contributes to the glucose-phosphate stress response. SetA is a proton motive force-driven efflux pump capable of transporting various sugars and sugar analogs in vitro. This study demonstrates that setA expression is induced in response to glucose-phosphate stress, and this requires SgrR. Under stress conditions, setA is cotranscribed with sgrS from the sgrS promoter. A setA mutant exhibits a growth defect under stress conditions that can be complemented by setA in trans, suggesting that SetA contributes to the optimal cellular recovery from stress. Despite previous in vitro evidence that SetA can promote efflux of the stress-causing glucose analog α-methyl glucoside, in vivo data in this study indicate that SetA is not the major efflux pump responsible for removal of α-methyl glucoside under stress conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.