ArticleThe American journal of pathology2010
Development of a bioengineered skin-humanized mouse model for psoriasis: dissecting epidermal-lymphocyte interacting pathways.
Article in The American journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Recent advances in immunocompetent human skin-on-chip models: Construction strategies and biomedical applications.Bioactive materials · 2026Review
- Can Microneedle-Nanocarrier Platforms Deliver True Tolerogenic Immunotherapy for Psoriasis?Vaccines · 2026Review
- Question-Driven Selection of Psoriasis Animal Models: A Structured Narrative Review of 48 Model Records.Journal of inflammation research · 2026Review
- Effect of Systemic Administration of CD4Comparative medicine · 2023Article
- Review
- Semisupervised representative learning for measuring epidermal thickness in human subjects in optical coherence tomography by leveraging datasets from rodent models.Journal of biomedical optics · 2022Article
- Elastin-Plasma Hybrid Hydrogels for Skin Tissue Engineering.Polymers · 2021Article
- Effect of Fibrin Concentration on the In Vitro Production of Dermo-Epidermal Equivalents.International journal of molecular sciences · 2021Article
- Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse Model.The journal of investigative dermatology. Symposium proceedings · 2020Review
- Efficient CRISPR-Cas9-Mediated Gene Ablation in Human Keratinocytes to Recapitulate Genodermatoses: Modeling of Netherton Syndrome.Molecular therapy. Methods & clinical development · 2020Article
- A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin.Scientific reports · 2020Article
- Bioprinting for Skin.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Infiltration of T Cells into a Three-Dimensional Psoriatic Skin Model Mimics Pathological Key Features.International journal of molecular sciences · 2019Article
- Bioengineered Skin Intended for Skin Disease Modeling.International journal of molecular sciences · 2019Review
- Humanized Mouse Models for the Study of Human Malaria Parasite Biology, Pathogenesis, and Immunity.Frontiers in immunology · 2018Review
- Contribution ofMediators of inflammation · 2017Review
- Asymmetric stem-cell division ensures sustained keratinocyte hyperproliferation in psoriatic skin lesions.International journal of molecular medicine · 2016Article
- Oxidative stress and mitochondrial dysfunction in Kindler syndrome.Orphanet journal of rare diseases · 2014Article
- Study of in vitro capillary-like structures in psoriatic skin substitutes.BioResearch open access · 2014Article
- Crosstalk between keratinocytes and T cells in a 3D microenvironment: a model to study inflammatory skin diseases.The Journal of investigative dermatology · 2014Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past few years, whole skin xenotransplantation models that mimic different aspects of psoriasis have become available. However, these models are strongly constrained by the lack of skin donor availability and homogeneity. We present in this study a bioengineering-based skin-humanized mouse model for psoriasis, either in an autologous version using samples derived from psoriatic patients or, more importantly, in an allogeneic context, starting from skin biopsies and blood samples from unrelated healthy donors. After engraftment, the regenerated human skin presents the typical architecture of normal human skin but, in both cases, immunological reconstitution through intradermal injection in the regenerated skin using in vitro-differentiated T1 subpopulations as well as recombinant IL-17 and IL-22 Th17 cytokines, together with removal of the stratum corneum barrier by a mild abrasive treatment, leads to the rapid conversion of the skin into a bona fide psoriatic phenotype. Major hallmarks of psoriasis were confirmed by the evaluation of specific epidermal differentiation and proliferation markers as well as the mesenchymal milieu, including angiogenesis and infiltrate. Our bioengineered skin-based system represents a robust platform to reliably assess the molecular and cellular mechanisms underlying the complex interdependence between epidermal cells and the immune system. The system may also prove suitable to assess preclinical studies that test the efficacy of novel therapeutic treatments and to predict individual patient response to therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.