Evidence map›Paper›PMID 20971631›Full record

ReviewCurrent opinion in genetics & development2010

Oscillatory signaling processes: the how, the why and the where.

Raymond Cheong, Andre Levchenko

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Signaling and actin waves at a glance.Journal of cell science · 2025
    Review
  2. Review
  3. Article
  4. Resonant learning in scale-free networks.PLoS computational biology · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Rhythmicity and waves in the cortex of single cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
  15. Review
  16. Article
  17. Approximating the stabilization of cellular metabolism by compartmentalization.Theory in biosciences = Theorie in den Biowissenschaften · 2016
    Article
  18. Article
  19. Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation.Integrative biology : quantitative biosciences from nano to macro · 2015
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Raymond CheongDepartment of Biomedical Engineering, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.
Andre Levchenko

Funding

Information tranfer in NF-kappaB and MAPK pathwaysR01GM072024 · NIGMS · YALE UNIVERSITY · PI LEVCHENKO, ANDRE · 2004 to 2019
$3.9M
An Integrative Analysis of MAPK Signaling in Budding YeastR01GM084332 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI LEVCHENKO, ANDRE · 2008 to 2011
$1.2M
NIGMS NIH HHS GM072024NIGMS NIH HHS GM084332NIGMS NIH HHS R01 GM072024NIGMS NIH HHS R01 GM084332
6 · The paper itself

Abstract

Oscillatory processes in biological signal transduction have come under progressively increasing scrutiny in terms of their functional significance and mechanisms of emergence and regulation. Since oscillatory processes can be a by-product of rapid adaptation and can also easily emerge if the feedback underlying adaptive processes is inadvertently artificially enhanced, one needs to exercise caution in both claiming the existence of in vivo oscillations and seeking to assign to them a specific functional significance. Nevertheless, oscillations can be a powerful means of encoding and transferring information both in time and in space, thus possessing important potential advantages for evolutionary selection and stabilization. Thus periodicity in the cell responses to diverse persistent external stimuli might become a more recognized and even expected feature of signaling processes.

Indexed as

Biological ClocksSignal TransductionAdaptation, PhysiologicalAnimalsHumans

Identifiers

PMID20971631
PMCPMC3895451

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.