ArticleFungal genetics and biology : FG & B2011
Ste50 adaptor protein governs sexual differentiation of Cryptococcus neoformans via the pheromone-response MAPK signaling pathway.
Article in Fungal genetics and biology : FG & B, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 43 citations in OpenAlex.
- Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating.Nature communications · 2026Article
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- The Adaptor Protein UvSte50 Governs Fungal Pathogenicity ofJournal of fungi (Basel, Switzerland) · 2022Article
- Role of the Heme Activator Protein Complex in the Sexual Development of Cryptococcus neoformans.mSphere · 2022Article
- SsUbc2, a determinant of pathogenicity, functions as a key coordinator controlling global transcriptomic reprogramming during mating in sugarcane smut fungus.Frontiers in microbiology · 2022Article
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- Functional Roles of Homologous Recombination and Non-Homologous End Joining in DNA Damage Response and Microevolution inJournal of fungi (Basel, Switzerland) · 2021Article
- Comparative transcriptomic analysis for identification of candidate sex-related genes and pathways in Crimson seabream (Parargyrops edita).Scientific reports · 2021Article
- A Signature-Tagged Mutagenesis (STM)-based murine-infectivity assay for Cryptococcus neoformans.Journal of microbiology (Seoul, Korea) · 2020Article
- Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans.Nature communications · 2020Article
- Functional Properties of the MAP Kinase UeKpp2 inFrontiers in microbiology · 2020Article
- The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis ofAnnual review of genetics · 2019Review
- Life Cycle ofAnnual review of microbiology · 2019Review
- Article
- Evolutionarily Conserved and Divergent Roles of Unfolded Protein Response (UPR) in the Pathogenic Cryptococcus Species Complex.Scientific reports · 2018Article
- Sho1 and Msb2 Play Complementary but Distinct Roles in Stress Responses, Sexual Differentiation, and Pathogenicity ofFrontiers in microbiology · 2018Article
- Article
- Unique roles of the unfolded protein response pathway in fungal development and differentiation.Scientific reports · 2016Article
- Systematic functional profiling of transcription factor networks in Cryptococcus neoformans.Nature communications · 2015Article
- Distinct and redundant roles of protein tyrosine phosphatases Ptp1 and Ptp2 in governing the differentiation and pathogenicity of Cryptococcus neoformans.Eukaryotic cell · 2014Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The mitogen-activated protein kinase (MAPK) pathways control diverse cellular functions in pathogenic fungi, including sexual differentiation, stress response, and maintenance of cell wall integrity. Here we characterized a Cryptococcus neoformans gene, which is homologous to the yeast Ste50 that is known to play an important role in mating pheromone response and stress response as an adaptor protein to the Ste11 MAPK kinase kinase in Saccharomyces cerevisiae. The C. neoformans Ste50 was not involved in any of the stress responses or virulence factor production (capsule and melanin) that are controlled by the HOG and Ras/cAMP signaling pathways. However, Ste50 was required for mating in both serotype A and serotype D C. neoformans strains. The ste50Δ mutant was completely defective in cell-cell fusion and mating pheromone production. Double mutation of the STE50 gene blocked increased production of pheromone and the hyper-filamentation phenotype of cells deleted of the CRG1 gene, which encodes the RGS protein that negatively regulates pheromone responsive G-protein signaling via the MAPK pathway. Regardless of the presence of the basidiomycota-specific SH3 domains of Ste50 that are known to be required for full virulence of Ustilago maydis, Ste50 was dispensable for virulence of C. neoformans in a murine model of cryptococcosis. In conclusion, the Ste50 adaptor protein controls sexual differentiation of C. neoformans via the pheromone-responsive MAPK pathway but is not required for virulence.
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