ArticleNeuroscience letters2011
Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain.
Article in Neuroscience letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Nootropic benzothiazoles promote dendritic spine formation by targeting fascin-1.The Journal of biological chemistry · 2025Article
- Altered GM1 catabolism affects NMDAR-mediated CaCell reports · 2024Article
- Calcineurin inhibition protects against dopamine toxicity and attenuates behavioral decline in a Parkinson's disease model.Cell & bioscience · 2023Article
- Non-Apoptotic Caspase-3 Activation Mediates Early Synaptic Dysfunction of Indirect Pathway Neurons in the Parkinsonian Striatum.International journal of molecular sciences · 2022Article
- Benzothiazole amphiphiles promote RasGRF1-associated dendritic spine formation in human stem cell-derived neurons.FEBS open bio · 2020Article
- Early Effects of Cyclophosphamide, Methotrexate, and 5-Fluorouracil on Neuronal Morphology and Hippocampal-Dependent Behavior in a Murine Model.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Altered expression of insulin-degrading enzyme and regulator of calcineurin in the rat intracerebral streptozotocin model and human apolipoprotein E-ε4-associated Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- Recent Topics on The Mechanisms of Immunosuppressive Therapy-Related Neurotoxicities.International journal of molecular sciences · 2019Review
- Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain.Journal of neurochemistry · 2018Article
- Cause or compensation?-Altered neuronal CaCNS neuroscience & therapeutics · 2018Review
- Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity.Neuroreport · 2017Article
- Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model.Molecular neurodegeneration · 2017Article
- Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets.Pharmacological reviews · 2017Review
- A central role for calcineurin in protein misfolding neurodegenerative diseases.Cellular and molecular life sciences : CMLS · 2017Review
- 5-Fluorouracil chemotherapy upregulates cytokines and alters hippocampal dendritic complexity in aged mice.Behavioural brain research · 2017Article
- Knockdown of pp32 Increases Histone Acetylation and Ameliorates Cognitive Deficits.Frontiers in aging neuroscience · 2017Article
- Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition.Journal of neuroinflammation · 2015Article
- Intra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm.Iranian journal of basic medical sciences · 2015Article
- Calcineurin-Crz1 signaling in lower eukaryotes.Eukaryotic cell · 2014Review
- FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines.Journal of biosciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Calcineurin has been implicated as part of a critical signaling pathway for learning and memory, and recent data suggest that calcineurin activation mediates some of the neurotoxicity of the Alzheimer related neurotoxin Aβ. Immunosuppression via calcineurin inhibition with the compound FK506 is an important treatment for organ transplant patients. Here we use Golgi impregnation techniques, along with a new survival analysis-based statistical approach for analysis of dendritic complexity, to show that in healthy adult mice one week of treatment with FK506 affects both the branching patterns and dendritic spine density of cortical neurons. These results indicate that calcineurin inhibition leads to readily detectable changes in brain morphology, further implicating calcineurin related pathways in both the function and structure of the adult brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.