ReviewChemico-biological interactions2011
Biological reactive intermediates (BRIs) formed from botanical dietary supplements.
Review in Chemico-biological interactions, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 33 citations in OpenAlex.
- Advances in the Chemical Properties and Functional Applications of Urushiol: From Traditional Lacquerware to Modern Materials.Polymers · 2026Review
- Myristicin and Elemicin: Potentially Toxic Alkenylbenzenes in Food.Foods (Basel, Switzerland) · 2022Review
- The Enigma of Bioactivity and Toxicity of Botanical Oils for Skin Care.Frontiers in pharmacology · 2020Review
- The Multiple Biological Targets of Hops and Bioactive Compounds.Chemical research in toxicology · 2019Review
- Formation and biological targets of botanical o-quinones.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Review
- Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States.Journal of traditional and complementary medicine · 2018Review
- The Prenylflavonoid Xanthohumol Reduces Alzheimer-Like Changes and Modulates Multiple Pathogenic Molecular Pathways in the Neuro2a/APPFrontiers in pharmacology · 2018Article
- The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites.The Journal of biological chemistry · 2017Article
- Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms.PloS one · 2013Article
- Pharmacodynamics of ginsenosides: antioxidant activities, activation of Nrf2, and potential synergistic effects of combinations.Chemical research in toxicology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The use of botanical dietary supplements is increasingly popular, due to their natural origin and the perceived assumption that they are safer than prescription drugs. While most botanical dietary supplements can be considered safe, a few contain compounds, which can be converted to biological reactive intermediates (BRIs) causing toxicity. For example, sassafras oil contains safrole, which can be converted to a reactive carbocation forming genotoxic DNA adducts. Alternatively, some botanical dietary supplements contain stable BRIs such as simple Michael acceptors that react with chemosensor proteins such as Keap1 resulting in induction of protective detoxification enzymes. Examples include curcumin from turmeric, xanthohumol from hops, and Z-ligustilide from dang gui. Quinones (sassafras, kava, black cohosh), quinone methides (sassafras), and epoxides (pennyroyal oil) represent BRIs of intermediate reactivity, which could generate both genotoxic and/or chemopreventive effects. The biological targets of BRIs formed from botanical dietary supplements and their resulting toxic and/or chemopreventive effects are closely linked to the reactivity of BRIs as well as dose and time of exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.