ArticleHeart rhythm2011
Termination of sustained atrial flutter and fibrillation using low-voltage multiple-shock therapy.
Article in Heart rhythm, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Clinical Feasibility Study to Evaluate the Safety and Performance of Low-Energy Unpinning Termination Therapy in Patients With VT
An International Clinical Feasibility Study to Evaluate the Safety and Performance of Low-Energy Unpinning Termination Therapy in Patients With VT/VF
A Clinical Feasibility Study to Evaluate the Safety and Performance of Low-Energy Therapy in Patients With Atrial Fibrillation Energy Therapy in Patients With Atrial Fibrillation
A Clinical Feasibility Study to Evaluate the Safety and Performance of Low-Energy Therapy in Patients With Atrial Fibrillation (US)
Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- In silico optical modulation of spiral wave trajectories in cardiac tissue.Pflugers Archiv : European journal of physiology · 2023Article
- Dissolution of spiral wave's core using cardiac optogenetics.PLoS computational biology · 2023Article
- Electrical Stimulation for Low-Energy Termination of Cardiac Arrhythmias: a Review.Cardiovascular drugs and therapy · 2023Review
- Novel Low-Voltage MultiPulse Therapy to Terminate Atrial Fibrillation.JACC. Clinical electrophysiology · 2021Article
- Article
- Termination of Scroll Waves by Surface Impacts.Physical review letters · 2019Article
- Conceptual Intra-Cardiac Electrode Configurations That Facilitate Directional Cardiac Stimulation for Optimal Electrotherapy.IEEE transactions on bio-medical engineering · 2019Article
- Low-energy defibrillation with nanosecond electric shocks.Cardiovascular research · 2017Article
- Highly trabeculated structure of the human endocardium underlies asymmetrical response to low-energy monophasic shocks.Chaos (Woodbury, N.Y.) · 2017Article
- Article
- A peptidomimetic inhibitor suppresses the inducibility of β1-adrenergic autoantibody-mediated cardiac arrhythmias in the rabbit.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2015Article
- Toward microendoscopy-inspired cardiac optogenetics in vivo: technical overview and perspective.Journal of biomedical optics · 2014Review
- Terminating ventricular tachyarrhythmias using far-field low-voltage stimuli: mechanisms and delivery protocols.Heart rhythm · 2013Article
- Interdependent Relationship Between Atrial Fibrillation and Sinus Rhythm at the Hypothetical Interface of Atrial Fibrillation, Autonomic Tone, Sinoatrial Node and Inflammation : Analytical Review, Reconsiderations, Speculations and New Insights.Journal of atrial fibrillation · 2012Review
- Processing and analysis of cardiac optical mapping data obtained with potentiometric dyes.American journal of physiology. Heart and circulatory physiology · 2012Review
- Three-dimensional mechanisms of increased vulnerability to electric shocks in myocardial infarction: altered virtual electrode polarizations and conduction delay in the peri-infarct zone.The Journal of physiology · 2012Article
- Mechanisms of ventricular arrhythmias: a dynamical systems-based perspective.American journal of physiology. Heart and circulatory physiology · 2012Review
- The Na+/K+ pump is an important modulator of refractoriness and rotor dynamics in human atrial tissue.American journal of physiology. Heart and circulatory physiology · 2012Article
- Low-energy multistage atrial defibrillation therapy terminates atrial fibrillation with less energy than a single shock.Circulation. Arrhythmia and electrophysiology · 2011Article
- Reversible cardiac conduction block and defibrillation with high-frequency electric field.Science translational medicine · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDefibrillation therapy for atrial fibrillation (AF) and flutter (AFl) is limited by pain induced by high-energy shocks. Thus, lowering the defibrillation energy for AFl/AF is desirable.
objectiveIn this study we applied low-voltage multiple-shock defibrillation therapy in a rabbit model of atrial tachyarrhythmias comparing its efficacy to single shocks and antitachycardia pacing (ATP).
methodsOptical mapping was performed in Langendorff-perfused rabbit hearts (n = 18). Acetylcholine (7 ± 5 to 17 ± 16 μM) was administered to promote sustained AFl and AF, respectively. Single and multiple monophasic shocks were applied within 1 or 2 cycle lengths (CLs) of the arrhythmia.
resultsWe observed AFl (CL = 83 ± 15 ms, n = 17) and AF (CL = 50 ± 8 ms, n = 11). ATP had a success rate of 66.7% in the case of AFl, but no success with AF (n = 9). Low-voltage multiple shocks had 100% success for both arrhythmias. Multiple low-voltage shocks terminated AFl at 0.86 ± 0.73 V/cm (within 1 CL) and 0.28 ± 0.13 V/cm (within 2 CLs), as compared with single shocks at 2.12 ± 1.31 V/cm (P < .001) and AF at 3.46 ± 3 V/cm (within 1 CL), as compared with single shocks at 6.83 ± 3.12 V/cm (P =.06). No ventricular arrhythmias were induced. Optical mapping revealed that termination of AFl was achieved by a properly timed, local shock-induced wave that collides with the arrhythmia wavefront, whereas AF required the majority of atrial tissue to be excited and reset for termination.
conclusionLow-voltage multiple-shock therapy terminates AFl and AF with different mechanisms and thresholds based on spatiotemporal characteristics of the arrhythmias.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.