ArticleDevelopmental biology2011
Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- The Dynamic Roles of Repressor Element 1-Silencing Transcription Factor (REST): A Double-Edged Sword in Neural Health and Disease.Molecular neurobiology · 2025Review
- A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer's disease.Nature communications · 2023Article
- Retinoblastoma tumor cell proliferation is negatively associated with an immune gene expression signature and increased immune cells.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia.Science advances · 2020Article
- On the Generation and Regeneration of Retinal Ganglion Cells.Frontiers in cell and developmental biology · 2020Article
- Article
- Opposing Effects of Growth and Differentiation Factors in Cell-Fate Specification.Current biology : CB · 2019Article
- An integrated transcriptional analysis of the developing human retina.Development (Cambridge, England) · 2019Article
- Systematic target function annotation of human transcription factors.BMC biology · 2018Article
- Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin.The Journal of cell biology · 2017Article
- Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Generation of Functional Human Retinal Ganglion Cells with Target Specificity from Pluripotent Stem Cells by Chemically Defined Recapitulation of Developmental Mechanism.Stem cells (Dayton, Ohio) · 2017Article
- The Importance of REST for Development and Function of Beta Cells.Frontiers in cell and developmental biology · 2017Review
- REST represses a subset of the pancreatic endocrine differentiation program.Developmental biology · 2015Article
- Continuous non-cell autonomous reprogramming to generate retinal ganglion cells for glaucomatous neuropathy.Stem cells (Dayton, Ohio) · 2015Article
- p120-catenin regulates REST and CoREST, and modulates mouse embryonic stem cell differentiation.Journal of cell science · 2014Article
- Article
- Overlapping spatiotemporal patterns of regulatory gene expression are required for neuronal progenitors to specify retinal ganglion cell fate.Vision research · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
As neuronal progenitors differentiate into neurons, they acquire a unique set of transcription factors. The transcriptional repressor REST prevents progenitors from undergoing differentiation. Notably, REST binding sites are often associated with retinal ganglion cell (RGC) genes whose expression in the retina is positively controlled by Atoh7, a factor essential for RGC formation. The key regulators that enable a retinal progenitor cell (RPC) to commit to an RGC fate have not been identified. We show here that REST suppresses RGC gene expression in RPCs. REST inactivation causes aberrant expression of RGC transcription factors in proliferating RPCs, independent of Atoh7, resulting in increased RGC formation. Strikingly, inactivating REST in Atoh7-null retinas restores transcription factor expression, which partially activates downstream RGC genes but is insufficient to prevent RGC loss. Our results demonstrate an Atoh7-independent program for initial activation of RGC genes and suggest a novel role for REST in preventing premature expression in RPCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.