ArticleMolecular microbiology2010
A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator.
Article in Molecular microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 199 papers.
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Who cites it
199 citing papers in PubMed.
- Spermidine is a common component of the eDNA-dependent biofilm matrix.NPJ biofilms and microbiomes · 2026Article
- A ComX-based strategy for artificially inducing competence in naturally non-transformableApplied and environmental microbiology · 2026Article
- AJournal of bacteriology · 2026Review
- Rgg/SHP transcriptional regulators, RaS-RiPPs, and their impacts in streptococci.F1000Research · 2026Review
- The adjacent ATP-binding protein-encoding genes of theJournal of bacteriology · 2025Article
- Aggregatibacter actinomycetemcomitans induces biofilm formation of Streptococcus sanguinis on titanium implants.International journal of implant dentistry · 2025Article
- Deciphering the role of SMU.1147 in peptide-mediated signaling and competence inMicrobiology spectrum · 2025Article
- The MutRS quorum-sensing system controls lantibiotic mutacin production in the human pathogenProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The phage protein paratox is a multifunctional metabolic regulator of Streptococcus.Nucleic acids research · 2025Article
- MecA inmSphere · 2024Article
- Review
- Extracellular proteolysis of tandemly duplicated pheromone propeptides affords additional complexity to bacterial quorum sensing.PLoS biology · 2024Article
- Genetic modification ofmSphere · 2024Article
- Quorum Sensing Inhibitors: An Alternative Strategy to Win the Battle against Multidrug-Resistant (MDR) Bacteria.Molecules (Basel, Switzerland) · 2024Review
- Unveiling the regulatory network controlling natural transformation in lactococci.PLoS genetics · 2024Article
- Mutation of the peptide-regulated transcription factor ComR for amidated peptide specificity and heterologous function inMicrobiology spectrum · 2024Article
- The Streptococcus phage protein paratox is an intrinsically disordered protein.Protein science : a publication of the Protein Society · 2024Article
- Bacterial quorum sensing orchestrates longitudinal interactions to shape microbiota assembly.Microbiome · 2023Article
- A Streptomyces tendae Specialized Metabolite Inhibits Quorum Sensing in Group A Streptococcus.Microbiology spectrum · 2023Article
- The ComRS-SigX Pathway Regulates Natural Transformation in Streptococcus ferus.Journal of bacteriology · 2023Article
139 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
All streptococcal genomes encode the alternative sigma factor SigX and 21 SigX-dependent proteins required for genetic transformation, yet no pyogenic streptococci are known to develop competence. Resolving this paradox may depend on understanding the regulation of sigX. We report the identification of a regulatory circuit linked to the sigX genes of mutans, pyogenic, and bovis streptococci that uses a novel small, double-tryptophan-containing sigX-inducing peptide (XIP) pheromone. In all three groups, the XIP gene (comS), and sigX have identical, non-canonical promoters consisting of 9 bp inverted repeats separated from a -10 hexamer by 19 bp. comS is adjacent to a gene encoding a putative transcription factor of the Rgg family and is regulated by its product, which we designate ComR. Deletion of comR or comS in Streptococcus mutans abolished transformability, as did deletion of the oligopeptide permease subunit oppD, suggesting that XIP is imported. Providing S. mutans with synthetic fragments of ComS revealed that seven C-terminal residues, including the WW motif, cause robust induction of both sigX and the competent state. We propose that this circuit is the proximal regulator of sigX in S. mutans, and we infer that it controls competence in a parallel way in all pyogenic and bovis streptococci.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.