Evidence map›Paper›PMID 20969583›Full record

ReviewImmunological reviews2010

Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors.

Motonari Kondo

Abstract readReview
In one paragraph

Review in Immunological reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed.

  1. Article
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  11. Beyond relapses: How BTK inhibitors are shaping the future of progressive MS treatment.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  12. Oyster mushroom fermentedAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2025
    Article
  13. Biomolecular condensates in immune cell fate.Nature reviews. Immunology · 2025
    Review
  14. Article
  15. Review
  16. Article
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  18. Article
  19. Inflammation in Development and Aging: Insights from the Zebrafish Model.International journal of molecular sciences · 2024
    Review
  20. Review

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Motonari KondoDepartment of Immunology, Duke University Medical Center, Durham, NC 27710, USA. motonari.kondo@duke.edu

Funding

IL-7 receptor signaling in lymphopoiesisR01AI056123 · NIAID · DUKE UNIVERSITY · PI KONDO, MOTONARI · 2004 to 2010
$2.1M
Commitment mechanisms in hemato/lymphopoiesisR01CA098129 · NCI · DUKE UNIVERSITY · PI KONDO, MOTONARI · 2004 to 2008
$1.4M
NCI NIH HHS R01 CA098129NIAID NIH HHS R01 AI056123
6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) continuously replenish all classes of blood cells through a series of lineage restriction steps that results in the progressive loss of differentiation potential to other cell lineages. This review focuses on the recent advances in understanding one of the earliest differentiation steps in HSC maturation, which involves the diversification of the lymphoid and myeloid cell lineages, the two major branches of hematopoietic cells. We discuss progress in the identification and characterization of progenitor populations downstream of HSCs, which has been a key to understanding the sequential biological events that take place along the course of differentiation into a certain hematopoietic cell type. We also discuss the importance of bone marrow microenvironment in lymphoid and myeloid lineage choice.

Indexed as

AnimalsBone MarrowCell LineageCytokinesHematopoiesisHumansLymphoid Progenitor CellsMultipotent Stem CellsMyeloid Progenitor CellsCytokines

Identifiers

PMID20969583
PMCPMC2975965

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.