ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2011
Parental smoking during pregnancy and offspring bone mass at age 10 years: findings from a prospective birth cohort.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Association between maternal smoking and child bone mineral density: a systematic review and meta-analysis.Environmental science and pollution research international · 2020Pooled it
- The Effect of Tobacco Smoking on Musculoskeletal Health: A Systematic Review.Journal of environmental and public health · 2018Pooled it
- Deciphering epigenetic regulation in cardiac developmental toxicity: Mechanisms and implications (Review).Molecular medicine reports · 2026Review
- Perturbations in Osteogenic Cell Fate Following Exposure to Constituents Present in Tobacco: A Combinatorial Study.Toxics · 2023Article
- Early Life Programming of Skeletal Health.Current osteoporosis reports · 2023Review
- Sidestream Smoke Extracts from Harm-Reduction and Conventional Camel Cigarettes Inhibit Osteogenic Differentiation via Oxidative Stress and Differential Activation of intrinsic Apoptotic Pathways.Antioxidants (Basel, Switzerland) · 2022Article
- Review
- Association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis.Clinical and experimental pediatrics · 2021Article
- Does the Trimester of Smoking Matter in the Association between Prenatal Smoking and the Risk of Early Childhood Caries?Caries research · 2021Article
- Prenatal smoking and the risk of early childhood caries: A prospective cohort study.Preventive medicine reports · 2020Article
- Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health.International journal of epidemiology · 2020Article
- Maternal smoking during pregnancy and fractures in offspring: national register based sibling comparison study.BMJ (Clinical research ed.) · 2020Article
- Associations of Prenatal Exposure to Cadmium With Child Growth, Obesity, and Cardiometabolic Traits.American journal of epidemiology · 2019Article
- Does cross-generational epigenetic inheritance contribute to cultural continuity?Environmental epigenetics · 2018Article
- Does fetal smoke exposure affect childhood bone mass? The Generation R Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Lifecourse relationship between maternal smoking during pregnancy, birth weight, contemporaneous anthropometric measurements and bone mass at 18years old. The 1993 Pelotas Birth Cohort.Early human development · 2014Article
- Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research.Journal of medical genetics · 2014Review
- Article
- Cohort Profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort.International journal of epidemiology · 2013Article
- The impact of smoking in the home on the health outcomes of non-smoker occupants in the UK.Tobacco induced diseases · 2013Article
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4 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledWe investigated an intrauterine influence of maternal smoking during pregnancy on childhood bone mass. Daughters, but not sons, of mothers who smoked had higher bone mass at age 10years. This appears to be due to familial factors related to parental smoking influencing increased offspring adiposity rather than a direct intrauterine effect.
introductionNeonatal studies have demonstrated an adverse relationship between maternal smoking in pregnancy and foetal bone mineral accrual. We aimed to investigate an intrauterine influence of maternal smoking during pregnancy on offspring bone mass at mean age 9.9 years.
methodsWe compared associations of maternal and paternal smoking in pregnancy with offspring total body less head (TBLH) and spine bone mineral content (BMC), bone area (BA), bone mineral density (BMD) and area-adjusted BMC (ABMC) in 7,121 children in the Avon Longitudinal Study of Parents and Children.
resultsMaternal smoking in any trimester was associated with increased TBLH BMC, BA and BMD in girls (mean difference [95% CI] (sex-specific SD scores), 0.13 [0.05-0.22], 0.13 [0.04-0.21], 0.13 [0.04-0.22], respectively) but not boys (0.01 [-0.07-0.09], 0.00 [-0.08-0.08], 0.04 [-0.05-0.12]), and also with spine BMC, BA and BMD in girls (0.13 [0.03-0.23], 0.12 [0.03-0.22], 0.10 [0.00-0.21]) but not boys (0.03 [-0.06-0.12], 0.00 [-0.09-0.09], 0.05 [-0.04-0.14]), but not with ABMC. Paternal smoking associations were similar, with no statistical evidence for a difference between maternal and paternal effects. Maternal associations increased on adjustment for offspring birth weight and gestational age, but attenuated to the null after adjustment for current height and weight.
conclusionsWe found little evidence that maternal smoking was related to bone mass in boys. In girls, maternal smoking associations were similar to those of paternal smoking, suggesting that these were attributable to shared familial characteristics, not intrauterine mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.