ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2011
Dopaminergic drugs and the risk of hip or femur fracture: a population-based case-control study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.
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- Bone health in Parkinson's disease: a systematic review and meta-analysis.Journal of neurology, neurosurgery, and psychiatry · 2014Pooled it
- Excess risk of fracture in incident Parkinson's disease Medicare beneficiaries.Injury epidemiology · 2026Article
- Bone health in Parkinson's disease: a comprehensive review of bone involvement and its pathophysiological mechanisms.Frontiers in medicine · 2025Review
- Fractures in Parkinson's Disease: injury patterns, hospitalization, and therapeutic aspects.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Article
- Effects of Neurological Disorders on Bone Health.Frontiers in psychology · 2020Review
- Risk of Hip Fracture in Older People Using Selective Serotonin Reuptake Inhibitors and Other Psychoactive Medicines Concurrently: A Matched Case-Control Study in Australia.Drugs - real world outcomes · 2017Article
- Risk Factors, Epidemiology and Treatment Strategies for Metabolic Bone Disease in Patients with Neurological Disease.Current osteoporosis reports · 2016Review
- Effects of depression and antidepressant medications on hip fracture: A population-based cohort study in Taiwan.Medicine · 2016Observational
- Medication use before and after hip fracture: a population-based cohort and case-control study.Drugs & aging · 2014Article
- Risk for femoral fractures in Parkinson's disease patients with and without severe functional impairment.PloS one · 2014Article
- Risk of fracture in patients with Parkinson's disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Article
- Article
- Calibration of FRAX ® 3.1 to the Dutch population with data on the epidemiology of hip fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Article
- Dopaminergic and serotonergic drug use: a nationwide register-based study of over 1,300,000 older people.PloS one · 2011Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryThe effect of dopaminergic medication on the risk of hip/femur fractures is not clear. Our results showed a nearly twofold increased risk of hip/femur fractures in current dopaminergic drug users. Concomitant use of antidepressants further increased this risk. Fracture risk assessment may be warranted in elderly users of dopaminergic drugs.
introductionDopaminergic drugs, often used in the treatment of Parkinson's disease, have several pharmacological effects that may increase or decrease the risk of falling and fractures. Thus, the effect of dopaminergic medication on the risk of hip/femur fractures is not clear. The objective of the study was to examine the effect of dopaminergic medication and concomitant use of psychotropics on the risk of hip/femur fractures taking into account the timing of dopaminergic drug use.
methodsA population-based case-control study in the PHARMO database was conducted for the period 1991 to 2002. Cases were patients aged 18 years and older with a first hip or femur fracture and matched to four control patients by year of birth, sex and geographical region.
resultsThe study population included 6,763 cases and 26,341 controls. Current use of dopaminergic drugs (1-30 days before the index date) was associated with an increased risk of hip/femur fractures compared to never use (OR(adj) 1.76, 95% CI = 1.39-2.22), but this excess risk rapidly dropped to baseline levels when treatment had been discontinued >1 year ago. Concomitant use of antidepressants among current dopaminergic drug users further increased the risk of hip/femur fractures (OR(adj) 3.51, 95% CI = 2.10-5.87) while there was no additional risk with concomitant use of other psychotropics.
conclusionsAlthough the observed association between dopaminergic drugs and fracture risk may not be entirely causal, due to absence of information on the (severity of the) underlying disease, fracture risk assessment may be warranted in elderly users of dopaminergic drugs.
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