ArticleChemical communications (Cambridge, England)2010
Selective labeling of polypeptides using protein farnesyltransferase via rapid oxime ligation.
Article in Chemical communications (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Engineering protein prenylation: an emerging tool for selective protein modification.Biochemical Society transactions · 2025Review
- A Not-So-Ancient Grease History: Click Chemistry and Protein Lipid Modifications.Chemical reviews · 2021Review
- Sequencing abasic sites in DNA at single-nucleotide resolution.Nature chemistry · 2019Article
- Recent progress in enzymatic protein labelling techniques and their applications.Chemical Society reviews · 2018Review
- Metabolic Labeling of Prenylated Proteins Using Alkyne-Modified Isoprenoid Analogues.Current protocols in chemical biology · 2018Article
- Exceptionally rapid oxime and hydrazone formation promoted by catalytic amine buffers with low toxicity.Chemical science · 2018Article
- Efficient farnesylation of an extended C-terminal C(The Journal of biological chemistry · 2018Article
- Oximes and Hydrazones in Bioconjugation: Mechanism and Catalysis.Chemical reviews · 2017Review
- Site-Specific, Covalent Immobilization of Dehalogenase ST2570 Catalyzed by Formylglycine-Generating Enzymes and Its Application in Batch and Semi-Continuous Flow Reactors.Molecules (Basel, Switzerland) · 2016Article
- Site-Specific PEGylation of Therapeutic Proteins.International journal of molecular sciences · 2015Review
- Application of meta- and para-Phenylenediamine as Enhanced Oxime Ligation Catalysts for Protein Labeling, PEGylation, Immobilization, and Release.Current protocols in protein science · 2015Article
- Engineering protein farnesyltransferase for enzymatic protein labeling applications.Bioconjugate chemistry · 2014Article
- Simultaneous dual protein labeling using a triorthogonal reagent.Journal of the American Chemical Society · 2013Article
- Enzymatic labeling of proteins: techniques and approaches.Bioconjugate chemistry · 2013Review
- Chemoenzymatic site-specific reversible immobilization and labeling of proteins from crude cellular extract without prior purification using oxime and hydrazine ligation.Current protocols in chemical biology · 2013Article
- Chemoenzymatic reversible immobilization and labeling of proteins without prior purification.Journal of the American Chemical Society · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
An aldehyde-containing alternative substrate for protein farnesyltransferase was prepared and shown to be enzymatically incorporated into a peptide and a protein. The protein was subsequently immobilized onto aminooxy-functionalized agarose beads or labeled with a fluorophore. This method for protein modification provides an alternative to the commonly employed Cu(I)-catalyzed click reaction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.