ArticlePLoS neglected tropical diseases2010
Coinfection with different Trypanosoma cruzi strains interferes with the host immune response to infection.
Article in PLoS neglected tropical diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Five-Year Experience of the Groupe de Recherche Action en Santé (GRAS) Clinical Laboratory, Burkina Faso, in Participating into an External Proficiency Testing (EPT) Programme.Diagnostics (Basel, Switzerland) · 2025Article
- Trypanosoma Cruzi Lineages Shape Macrophage Cytokine Profiles in Single and Mixed Infections.Parasite immunology · 2025Article
- Coinfection by multipleMicrobiology and molecular biology reviews : MMBR · 2025Review
- The Dominance of Coinfecting Parasites' Indirect Genetic Effects on Host Traits.The American naturalist · 2024Article
- New insights intoFrontiers in immunology · 2024Review
- Intra-hostMicrobiology spectrum · 2023Article
- Cytokine Networks as Targets for Preventing and Controlling Chagas Heart Disease.Pathogens (Basel, Switzerland) · 2023Review
- Differential Modulation of Mouse Heart Gene Expression by Infection With TwoFrontiers in genetics · 2020Article
- Leptin Functions in Infectious Diseases.Frontiers in immunology · 2018Review
- Small subunit ribosomal metabarcoding reveals extraordinary trypanosomatid diversity in Brazilian bats.PLoS neglected tropical diseases · 2017Article
- Rhodnius prolixus Life History Outcomes Differ when Infected with Different Trypanosoma cruzi I Strains.The American journal of tropical medicine and hygiene · 2015Article
- Genotype diversity of Trypanosoma cruzi in small rodents and Triatoma sanguisuga from a rural area in New Orleans, Louisiana.Parasites & vectors · 2015Article
- Article
- Human leucocyte antigen-G (HLA-G) and its murine functional homolog Qa2 in the Trypanosoma cruzi Infection.Mediators of inflammation · 2015Article
- Experimental evidence of biological interactions among different isolates of Trypanosoma cruzi from the Chaco Region.PloS one · 2015Article
- Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection.Cellular microbiology · 2014Article
- Acute Chagas disease induces cerebral microvasculopathy in mice.PLoS neglected tropical diseases · 2014Article
- A DTU-dependent blood parasitism and a DTU-independent tissue parasitism during mixed infection of Trypanosoma cruzi in immunosuppressed mice.Parasitology research · 2014Article
- Article
- Trypanosomes genetic diversity, polyparasitism and the population decline of the critically endangered Australian marsupial, the brush tailed bettong or woylie (Bettongia penicillata).International journal for parasitology. Parasites and wildlife · 2013Article
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A century after the discovery of Trypanosoma cruzi in a child living in Lassance, Minas Gerais, Brazil in 1909, many uncertainties remain with respect to factors determining the pathogenesis of Chagas disease (CD). Herein, we simultaneously investigate the contribution of both host and parasite factors during acute phase of infection in BALB/c mice infected with the JG and/or CL Brener T. cruzi strains. JG single infected mice presented reduced parasitemia and heart parasitism, no mortality, levels of pro-inflammatory mediators (TNF-α, CCL2, IL-6 and IFN-γ) similar to those found among naïve animals and no clinical manifestations of disease. On the other hand, CL Brener single infected mice presented higher parasitemia and heart parasitism, as well as an increased systemic release of pro-inflammatory mediators and higher mortality probably due to a toxic shock-like systemic inflammatory response. Interestingly, coinfection with JG and CL Brener strains resulted in intermediate parasitemia, heart parasitism and mortality. This was accompanied by an increase in the systemic release of IL-10 with a parallel increase in the number of MAC-3(+) and CD4(+) T spleen cells expressing IL-10. Therefore, the endogenous production of IL-10 elicited by coinfection seems to be crucial to counterregulate the potentially lethal effects triggered by systemic release of pro-inflammatory mediators induced by CL Brener single infection. In conclusion, our results suggest that the composition of the infecting parasite population plays a role in the host response to T. cruzi in determining the severity of the disease in experimentally infected BALB/c mice. The combination of JG and CL Brener was able to trigger both protective inflammatory immunity and regulatory immune mechanisms that attenuate damage caused by inflammation and disease severity in BALB/c mice.
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