ArticlePloS one2010
Genome-wide patterns of gene expression during aging in the African malaria vector Anopheles gambiae.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Warmer temperature accelerates senescence by modifying the aging-dependent changes in the mosquito transcriptome, altering immunity, metabolism, and DNA repair.Immunity & ageing : I & A · 2025Article
- MALDI-TOF MS Profiling and Its Contribution to Mosquito-Borne Diseases: A Systematic Review.Insects · 2024Review
- Rapid classification of epidemiologically relevant age categories of the malaria vector, Anopheles funestus.Parasites & vectors · 2024Article
- Evaluation of diffuse reflectance spectroscopy for predicting age, species, and cuticular resistance of Anopheles gambiae s.l under laboratory conditions.Scientific reports · 2023Article
- Use of transcriptional age grading technique to determine the chronological age of Sri Lankan Aedes aegypti and Aedes albopictus females.Parasites & vectors · 2021Article
- Age grading An. gambiae and An. arabiensis using near infrared spectra and artificial neural networks.PloS one · 2019Article
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- Article
- Ecophysiology of Anopheles gambiae s.l.: persistence in the Sahel.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014Review
- Needs for monitoring mosquito transmission of malaria in a pre-elimination world.The American journal of tropical medicine and hygiene · 2014Article
- Using a near-infrared spectrometer to estimate the age of anopheles mosquitoes exposed to pyrethroids.PloS one · 2014Article
- Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles gambiae.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Fine-scale analysis of parasite resistance genes in the red flour beetle, Tribolium castaneum.Genetics · 2013Article
- Transcriptional profiling of Drosophila S2 cells in early response to Drosophila C virus.Virology journal · 2013Article
- Article
- Proteomic analysis of salivary glands of female Anopheles barbirostris species A2 (Diptera: Culicidae) by two-dimensional gel electrophoresis and mass spectrometry.Parasitology research · 2012Article
- Aging field collected Aedes aegypti to determine their capacity for dengue transmission in the southwestern United States.PloS one · 2012Article
- Short report: The effect of preservation methods on predicting mosquito age by near infrared spectroscopy.The American journal of tropical medicine and hygiene · 2011Article
- Evaluating RNAlater® as a preservative for using near-infrared spectroscopy to predict Anopheles gambiae age and species.Malaria journal · 2011Article
- Drinking a hot blood meal elicits a protective heat shock response in mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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6 authors.
Funding
Abstract
The primary means of reducing malaria transmission is through reduction in longevity in days of the adult female stage of the Anopheles vector. However, assessing chronological age is limited to crude physiologic methods which categorize the females binomially as either very young (nulliparous) or not very young (parous). Yet the epidemiologically relevant reduction in life span falls within the latter category. Age-grading methods that delineate chronological age, using accurate molecular surrogates based upon gene expression profiles, will allow quantification of the longevity-reducing effects of vector control tools aimed at the adult, female mosquito. In this study, microarray analyses of gene expression profiles in the African malaria vector Anopheles gambiae were conducted during natural senescence of females in laboratory conditions. Results showed that detoxification-related and stress-responsive genes were up-regulated as mosquitoes aged. A total of 276 transcripts had age-dependent expression, independently of blood feeding and egg laying events. Expression of 112 (40.6%) of these transcripts increased or decreased monotonically with increasing chronologic age. Seven candidate genes for practical age assessment were tested by quantitative gene amplification in the An. gambiae G3 strain in a laboratory experiment and the Mbita strain in field enclosures set up in western Kenya under conditions closely resembling natural ones. Results were similar between experiments, indicating that senescence is marked by changes in gene expression and that chronological age can be gauged accurately and repeatedly with this method. These results indicate that the method may be suitable for accurate gauging of the age in days of field-caught, female An. gambiae.
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