Evidence map›Paper›PMID 20966969›Full record

ArticleNature reviews. Molecular cell biology2010

TRAPP complexes in membrane traffic: convergence through a common Rab.

Jemima Barrowman, Deepali Bhandari, Karin Reinisch, Susan Ferro-Novick

Abstract read
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In one paragraph

Article in Nature reviews. Molecular cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 175 citations in OpenAlex.

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  19. Biallelic truncating variants inJournal of medical genetics · 2022
    Article
  20. Trappc9 Deficiency Impairs the Plasticity of Stem Cells.International journal of molecular sciences · 2022
    Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jemima BarrowmanDepartment of Cell Biology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.
Deepali Bhandari
Karin Reinisch
Susan Ferro-Novick
Ferro (United States) · USYale University · US

Funding

The integral membrane protease ZMPSTE24, lamin A processing, and progeriaR01GM041223 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI MICHAELIS, SUSAN D. · 1989 to 2017
$5.0M
Regulatory Mechanisms in Membrane TraffickingR01GM080616 · NIGMS · YALE UNIVERSITY · PI REINISCH, KARIN M · 2007 to 2018
$4.1M
HHMINIGMS NIH HHS R01 GM41223NIGMS NIH HHS R01 GM80616
6 · The paper itself

Abstract

Transport protein particle (TRAPP; also known as trafficking protein particle), a multimeric guanine nucleotide-exchange factor for the yeast GTPase Ypt1 and its mammalian homologue, RAB1, regulates multiple membrane trafficking pathways. TRAPP complexes exist in three forms, each of which activates Ypt1 or RAB1 through a common core of subunits and regulates complex localization through distinct subunits. Whereas TRAPPI and TRAPPII tether coated vesicles during endoplasmic reticulum to Golgi and intra-Golgi traffic, respectively, TRAPPIII has recently been shown to be required for autophagy. These advances illustrate how the TRAPP complexes link Ypt1 and RAB1 activation to distinct membrane-tethering events.

Indexed as

AnimalsCarrier ProteinsEndoplasmic ReticulumGolgi ApparatusGuanine Nucleotide Exchange FactorsHumansIntercellular Signaling Peptides and ProteinsModels, BiologicalMutationrab1 GTP-Binding ProteinsVesicular Transport ProteinsCarrier ProteinsGuanine Nucleotide Exchange FactorsIntercellular Signaling Peptides and Proteinsrab1 GTP-Binding Proteinstransport protein particle, TRAPPTRAPPC9 protein, humanVesicular Transport Proteins

Identifiers

PMID20966969
OpenAlexW2010297881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.