Evidence map›Paper›PMID 20966923›Full record

ReviewNature reviews. Cancer2010

Walls around tumours - why plants do not develop cancer.

John H Doonan, Robert Sablowski

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Fraternal cooperation of hierarchical cancer parallels metazoan multicellularity and eusociality.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  5. Article
  6. Cellular and Molecular Regulatory Signals in Root Growth and Development.International journal of molecular sciences · 2025
    Article
  7. Histopathology ofPlants (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Review
  10. The Evolutionary Interplay of Somatic and Germline Mutation Rates.Annual review of biomedical data science · 2024
    Review
  11. Whole-Genome Sequencing and Analysis of Tumour-Forming Radish (International journal of molecular sciences · 2024
    Article
  12. Review
  13. Reuniting philosophy and science to advance cancer research.Biological reviews of the Cambridge Philosophical Society · 2023
    Article
  14. Review
  15. Review
  16. Use ofHeliyon · 2023
    Article
  17. Review
  18. Modeling cancer's ecological and evolutionary dynamics.Medical oncology (Northwood, London, England) · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

John H DoonanJohn Innes Centre, Conley Lane, Norwich NR4 7UH, UK. john.doonan@bbsrc.ac.uk
Robert Sablowski
John Innes Centre · GB

Funding

Biotechnology and Biological Sciences Research Council BB/D52189X/1Biotechnology and Biological Sciences Research Council BBS/E/J/00000129Biotechnology and Biological Sciences Research Council BBS/E/J/00000594
6 · The paper itself

Abstract

In plants, as in animals, most cells that constitute the organism limit their reproductive potential in order to provide collective support for the immortal germ line. And, as in animals, the mechanisms that restrict the proliferation of somatic cells in plants can fail, leading to tumours. There are intriguing similarities in tumorigenesis between plants and animals, including the involvement of the retinoblastoma pathway as well as overlap with mechanisms that are used for stem cell maintenance. However, plant tumours are less frequent and are not as lethal as those in animals. We argue that fundamental differences between plant and animal development make it much more difficult for individual plant cells to escape communal controls.

Indexed as

Neoplasms, ExperimentalPlant DiseasesAnimalsCell ProliferationHumansSignal TransductionStem Cells

Identifiers

PMID20966923
OpenAlexW2014414522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.