SynthesisSexually transmitted infections2011
Will circumcision provide even more protection from HIV to women and men? New estimates of the population impact of circumcision interventions.
Synthesis in Sexually transmitted infections, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Association between male circumcision and women's biomedical health outcomes: a systematic review.The Lancet. Global health · 2017Pooled it
- Guideline
- HIV shedding from male circumcision wounds in HIV-infected men: a prospective cohort study.PLoS medicine · 2015Trial
- Effect of text messaging to deter early resumption of sexual activity after male circumcision for HIV prevention: a randomized controlled trial.Journal of acquired immune deficiency syndromes (1999) · 2014Trial
- Does the evidence support circumcision of infant males in the United Kingdom?-a systematic review.Translational andrology and urology · 2026Review
- Dissemination of the Spear & Shield Project using a Training of Trainers Model: A reflection on challenges and successes.Translational behavioral medicine · 2022Article
- Perceived HIV-protective benefits of male circumcision: Risk compensatory behaviour among women in Malawi.PloS one · 2019Article
- Females' Peer Influence and Support for Adolescent Males Receiving Voluntary Medical Male Circumcision Services.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- The emerging health impact of voluntary medical male circumcision in Zimbabwe: An evaluation using three epidemiological models.PloS one · 2018Article
- "Now that you are circumcised, you cannot have first sex with your wife": post circumcision sexual behaviours and beliefs among men in Wakiso district, Uganda.Journal of the International AIDS Society · 2017Article
- CDC's Male Circumcision Recommendations Represent a Key Public Health Measure.Global health, science and practice · 2017Article
- Early infant male circumcision: Systematic review, risk-benefit analysis, and progress in policy.World journal of clinical pediatrics · 2017Article
- Early resumption of sexual activity following voluntary medical male circumcision in Botswana: A qualitative study.PloS one · 2017Article
- Article
- Female Partner Acceptance as a Predictor of Men's Readiness to Undergo Voluntary Medical Male Circumcision in Zambia: The Spear and Shield Project.AIDS and behavior · 2016Article
- Effectiveness of and Financial Returns to Voluntary Medical Male Circumcision for HIV Prevention in South Africa: An Incremental Cost-Effectiveness Analysis.PLoS medicine · 2016Article
- Potential impact of multiple interventions on HIV incidence in a hyperendemic region in Western Kenya: a modelling study.BMC infectious diseases · 2016Article
- Women's Perceptions and Misperceptions of Male Circumcision: A Mixed Methods Study in Zambia.PloS one · 2016Article
- Healthcare providers' knowledge, attitudes and practices towards medical male circumcision and their understandings of its partial efficacy in HIV prevention: Qualitative research in KwaZulu-Natal, South Africa.International journal of nursing studies · 2016Article
- Sexual Satisfaction, Performance, and Partner Response Following Voluntary Medical Male Circumcision in Zambia: The Spear and Shield Project.Global health, science and practice · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundMathematical modelling has indicated that expansion of male circumcision services in high HIV prevalence settings can substantially reduce population-level HIV transmission. However, these projections need revision to incorporate new data on the effect of male circumcision on the risk of acquiring and transmitting HIV.
methodsRecent data on the effect of male circumcision during wound healing and the risk of HIV transmission to women were synthesised based on four trials of circumcision among adults and new observational data of HIV transmission rates in stable partnerships from men circumcised at younger ages. New estimates were generated for the impact of circumcision interventions in two mathematical models, representing the HIV epidemics in Zimbabwe and Kisumu, Kenya. The models did not capture the interaction between circumcision, HIV and other sexually transmitted infections.
resultsAn increase in the risk of HIV acquisition and transmission during wound healing is unlikely to have a major impact of circumcision interventions. However, it was estimated that circumcision confers a 46% reduction in the rate of male-to-female HIV transmission. If this reduction begins 2 years after the procedure, the impact of circumcision is substantially enhanced and accelerated compared with previous projections with no such effect-increasing by 40% the infections averted by the intervention overall and doubling the number of infections averted among women.
conclusionsCommunities, and especially women, may benefit much more from circumcision interventions than had previously been predicted, and these results provide an even greater imperative to increase scale-up of safe male circumcision services.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.