Trial reportStroke2010
Impaired leg vasodilatory function after stroke: adaptations with treadmill exercise training.
Trial report in Stroke, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 7 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Peripheral vascular function in stroke: systematic review and meta-analysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Pooled it
- Physical fitness training for stroke patients.The Cochrane database of systematic reviews · 2020Pooled it
- Factors Influencing the Efficacy of Aerobic Exercise for Improving Fitness and Walking Capacity After Stroke: A Meta-Analysis With Meta-Regression.Archives of physical medicine and rehabilitation · 2017Pooled it
- Physical fitness training for stroke patients.The Cochrane database of systematic reviews · 2016Pooled it
- Treadmill training and body weight support for walking after stroke.The Cochrane database of systematic reviews · 2014Pooled it
- What is the evidence for physical therapy poststroke? A systematic review and meta-analysis.PloS one · 2014Pooled it
- Comparative effectiveness of aerobic training intensities in chronic stroke: a network meta-analysis of randomized controlled trials.Frontiers in neurologyPooled it
- Exercise Effect on Cerebral Artery Hemodynamic and Morphology in Stroke Patients: A Randomized Trial.CNS neuroscience & therapeutics · 2026Trial
- A Randomized Clinical Trial of a Functional Electrical Stimulation Mimic to Gait Promotes Motor Recovery and Brain Remodeling in Acute Stroke.Behavioural neurology · 2018Trial
- Higher Treadmill Training Intensity to Address Functional Aerobic Impairment after Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2015Trial
- Acute passive vibration reduces arterial stiffness and aortic wave reflection in stroke survivors.European journal of applied physiology · 2014Trial
- Test-retest reliability and minimal detectable change of pulse wave velocity and flow-mediated dilation in paretic and non-paretic limbs of older adults post-stroke.Physiological reports · 2026Article
- Stroke Increases Neuromuscular Fatigability in Females but not Males during Isometric Exercise.Medicine and science in sports and exercise · 2026Article
- Ischemic stroke reduces bone perfusion and alters osteovascular structure.Bone reports · 2025Article
- High-Intensity Exercise Training Impact on Cardiorespiratory Fitness, Gait Ability, and Balance in Stroke Survivors: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Noninvasive estimation of skeletal muscle oxygen consumption rate and microvascular reactivity in chronic stroke survivors using near-infrared spectroscopy.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Stroke-induced excess in capillarization relative to oxidative capacity in rats is muscle specific.Physiological reports · 2024Article
- Preventative Sensor-Based Remote Monitoring of the Diabetic Foot in Clinical Practice.Sensors (Basel, Switzerland) · 2023Article
- Associations Between Time After Stroke and Exercise Training Outcomes: A Meta-Regression Analysis.Journal of the American Heart Association · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeResting and reactive hyperemic leg blood flows are significantly reduced in the paretic compared with the nonparetic limb after disabling stroke. Our objective was to compare the effects of regular treadmill exercise (TM) with an active control regimen of supervised stretching (CONTROL) on peripheral hemodynamic function.
methodsThis intervention study used a randomized, controlled design, in which participants were randomized with stratification according to age and baseline walking capacity to ensure approximate balance between the 2 groups. Fifty-three chronic, ischemic stroke participants (29 TM and 24 CONTROL) with mild to moderate hemiparetic gait completed bilateral measurements of lower leg resting and reactive hyperemic blood flow using venous occlusion strain gauge plethysmography before and after the 6-month intervention period. Participants also underwent testing to track changes in peak aerobic fitness across time.
resultsResting and reactive hyperemic blood flows were significantly reduced in the paretic compared with the nonparetic limb at baseline before any intervention (-28% and -34%, respectively, P<0.01). TM increased both resting and reactive hyperemic blood flow in the paretic limb by 25% compared with decreases in CONTROL (P<0.001, between groups). Similarly, nonparetic leg blood flow was significantly improved with TM compared with controls (P<0.001). Peak aerobic fitness improved by 18% in TM and decreased by 4% in CONTROL (P<0.01, between groups), and there was a significant relationship between blood flow change and peak fitness change for the group as a whole (r=.30, P<0.05).
conclusionsPeripheral hemodynamic function improves with regular aerobic exercise training after disabling stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.