ArticleArteriosclerosis, thrombosis, and vascular biology2011
The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- Interleukin-19 Regulates Adipose Tissue Dysfunction in Obesity: Interplay Between Inflammation and Vascularization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Lethality is local, but survival is systemic: Temporal and multi-organ responses to chlorine gas exposure in a murine model.Current research in toxicology · 2026Article
- Causal effects of circulating inflammatory proteins on colorectal cancer: a Mendelian randomization and Spatial transcriptomic study.Discover oncology · 2025Article
- IL-19 Is a Novel Lymphangiocrine Factor Inducing Lymphangiogenesis and Lymphatic Junctional Regulation.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Protein Identification for Stroke Progression via Mendelian Randomization in Million Veteran Program and UK Biobank.Stroke · 2024Article
- Anti-Ferroptotic Treatment Deteriorates Myocardial Infarction by Inhibiting Angiogenesis and Altering Immune Response.Antioxidants (Basel, Switzerland) · 2024Article
- Review
- Recombinant Interleukin-19 Suppresses the Formation and Progression of Experimental Abdominal Aortic Aneurysms.Journal of the American Heart Association · 2021Article
- miR-129a-3p Inhibits PEDV Replication by Targeting the EDA-Mediated NF-κB Pathway in IPEC-J2 Cells.International journal of molecular sciences · 2021Article
- Interleukin 20 receptor A expression in colorectal cancer and its clinical significance.PeerJ · 2021Article
- Regulation of pro- and anti-atherogenic cytokines.Cytokine · 2019Review
- RNA stability protein ILF3 mediates cytokine-induced angiogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation.Frontiers in immunology · 2019Article
- IL-20 receptor cytokines in autoimmune diseases.Journal of leukocyte biology · 2018Review
- Treatment with IL-19 improves locomotor functional recovery after contusion trauma to the spinal cord.British journal of pharmacology · 2018Article
- The roles of interleukins in perfusion recovery after peripheral arterial disease.Bioscience reports · 2018Review
- Induction of MiR133a expression by IL-19 targets LDLRAP1 and reduces oxLDL uptake in VSMC.Journal of molecular and cellular cardiology · 2017Article
- The association between interleukin-19 concentration and diabetic nephropathy.BMC nephrology · 2017Article
- Association between interleukin-19 and angiopoietin-2 with vascular complications in type 2 diabetes.Journal of diabetes investigation · 2016Article
- Interleukin-19 induces angiogenesis in the absence of hypoxia by direct and indirect immune mechanisms.American journal of physiology. Cell physiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo characterize the expression and function of interleukin (IL) 19, a recently described T-helper 2 anti-inflammatory IL, on endothelial cell (EC) pathophysiological features. METHODS AND
resultsThe expression and effects of anti-inflammatory ILs on EC activation and development of angiogenesis are uncharacterized. We demonstrate by immunohistochemistry and immunoblot that IL-19 is expressed in inflamed, but not normal, human coronary endothelium and can be induced in cultured human ECs by serum and basic fibroblast growth factor. IL-19 is mitogenic and chemotactic, and it promotes EC spreading. IL-19 activates the signaling proteins STAT3, p44/42, and Rac1. In functional ex vivo studies, IL-19 promotes cordlike structure formation of cultured ECs and enhances microvessel sprouting in the mouse aortic ring assay. IL-19 induces tube formation in gelatinous protein (Matrigel) plugs in vivo.
conclusionsTo our knowledge, these data are the first to report expression of the anti-inflammatory agent, IL-19, in ECs; and the first to indicate that IL-19 is mitogenic and chemotactic for ECs and can induce the angiogenic potential of ECs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.