ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Maternal dietary tryptophan deficiency alters cardiorespiratory control in rat pups.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 47 citations in OpenAlex.
- Tryptophan's Journey Through Pregnancy: The Role of Serotonin.International journal of tryptophan research : IJTR · 2026Review
- Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part II. Age-associated alterations in serotonin receptor binding profiles within medullary nuclei supporting cardiorespiratory homeostasis.Journal of neuropathology and experimental neurology · 2024Article
- Multigenerational inheritance of breathing deficits following perinatal exposure to titanium dioxide nanoparticles in the offspring of mice.Discover nano · 2024Article
- Tryptophan in the mouse diet is essential for embryo implantation and decidualization.Frontiers in endocrinology · 2024Article
- Perspective: Gestational Tryptophan Fluctuation Altering Neuroembryogenesis and Psychosocial Development.Cells · 2022Article
- Developmental Programming and Reprogramming of Hypertension and Kidney Disease: Impact of Tryptophan Metabolism.International journal of molecular sciences · 2020Review
- Pre- and early postnatal nicotine exposure exacerbates autoresuscitation failure in serotonin-deficient rat neonates.The Journal of physiology · 2018Article
- Medullary 5-HT neurons: Switch from tonic respiratory drive to chemoreception during postnatal development.Neuroscience · 2017Article
- Sudden Unexpected Death in Fetal Life Through Early Childhood.Pediatrics · 2016Article
- Eliminating medullary 5-HT neurons delays arousal and decreases the respiratory response to repeated episodes of hypoxia in neonatal rat pups.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- A Short-Term Fasting in Neonates Induces Breathing Instability and Epigenetic Modification in the Carotid Body.Advances in experimental medicine and biology · 2015Article
- Medullary serotonin neurons are CO2 sensitive in situ.Journal of neurophysiology · 2013Article
- Sudden and unexpected death in early life: proceedings of a symposium in honor of Dr. Henry F. Krous.Forensic science, medicine, and pathology · 2012Review
- Subtle alterations in breathing and heart rate control in the 5-HT1A receptor knockout mouse in early postnatal development.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Serotonin transporter null male mouse pups have lower ventilation in air and 5% CO2 at postnatal ages P15 and P25.Respiratory physiology & neurobiology · 2011Article
- Brainstem serotonin deficiency in the neonatal period: autonomic dysregulation during mild cold stress.The Journal of physiology · 2011Article
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7 authors at 1 institution in 1 country.
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Abstract
Malnutrition during pregnancy adversely affects postnatal forebrain development; its effect upon brain stem development is less certain. To evaluate the role of tryptophan [critical for serotonin (5-HT) synthesis] on brain stem 5-HT and the development of cardiorespiratory function, we fed dams a diet ∼45% deficient in tryptophan during gestation and early postnatal life and studied cardiorespiratory variables in the developing pups. Deficient pups were of normal weight at postnatal day (P)5 but weighed less than control pups at P15 and P25 (P < 0.001) and had lower body temperatures at P15 (P < 0.001) and P25 (P < 0.05; females only). Oxygen consumption (Vo(2)) was unaffected. At P15, deficient pups had an altered breathing pattern and slower heart rates. At P25, they had significantly lower ventilation (Ve) and Ve-to-Vo(2) ratios in both air and 7% CO(2). The ventilatory response to CO(2) (% increase in Ve/Vo(2)) was significantly increased at P5 (males) and reduced at P15 and P25 (males and females). Deficient pups had 41-56% less medullary 5-HT (P < 0.01) compared with control pups, without a difference in 5-HT neuronal number. These data indicate important interactions between nutrition, brain stem physiology, and age that are potentially relevant to understanding 5-HT deficiency in the sudden infant death syndrome.
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