Trial reportClinical journal of the American Society of Nephrology : CJASN2011
Equations to estimate creatinine excretion rate: the CKD epidemiology collaboration.
Trial report in Clinical journal of the American Society of Nephrology : CJASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 189 citations in OpenAlex.
- Urinary sodium excretion and dietary sources of sodium intake in community-dwelling Chinese adults aged 50 years and over.Public health nutrition · 2021Trial
- Glucocorticoids affect metabolic but not muscle microvascular insulin sensitivity following high versus low salt intake.JCI insight · 2020Trial
- Creatinine generation from kinetic modeling with or without postdialysis serum creatinine measurement: results from the HEMO study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Trial
- Salt intake and blood pressure response to percutaneous renal denervation in resistant hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2017Trial
- Urine Potassium Excretion, Kidney Failure, and Mortality in CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Trial
- Spot urine sodium measurements do not accurately estimate dietary sodium intake in chronic kidney disease.The American journal of clinical nutrition · 2016Trial
- Trial
- Association between serum uric acid to creatinine ratio with metabolic profile in subjects with non-alcoholic fatty liver disease (NAFLD).BMC endocrine disorders · 2025Article
- Medullary sponge kidney: in-depth phenotyping for a better understanding of functional and structural abnormalities.Journal of nephrology · 2025Article
- Reference intervals for urine creatinine-to-specific gravity ratio as an indicator of relative creatinine excretion rate: a cross-sectional study.Annals of medicine and surgery (2012) · 2025Article
- Optimizing Screening Performance for the Risk of Hyperoxaluria and Urolithiasis Using the Urinary Oxalate/Creatinine Ratio: A Retrospective Analysis.European urology open science · 2025Article
- Association of cystatin C kidney function measures with motoric cognitive risk syndrome: evidence from two cohort studies.The journal of nutrition, health & aging · 2025Article
- Prediction of one-day creatinine excretion in Japanese schoolchildren based on anthropometric measurements.Environmental health and preventive medicine · 2025Article
- Comparing estimated protein excretion rate and spot urinary protein-creatinine ratio in assessing urinary protein excretion in patients with kidney disease in China: a single center study.Frontiers in medicine · 2025Article
- Employing urinary biomarkers to infer the absence of acute kidney disease in outpatients with a single serum creatinine measurement.Renal failure · 2024Article
- Exploring Adiposity and Chronic Kidney Disease: Clinical Implications, Management Strategies, Prognostic Considerations.Medicina (Kaunas, Lithuania) · 2024Review
- Association of urinary creatinine excretion and body mass index with diabetic retinopathy in patients with type 2 diabetes.Scientific reports · 2024Article
- Kidney phosphate wasting predicts poor outcome in polycystic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Observational
- Measuring Albuminuria in Individuals With Obesity: Pitfalls of the Urinary Albumin-Creatinine Ratio.Kidney medicine · 2024Review
- The Fruit and Veggies for Kidney Health Study: A Prospective Randomized Trial.Kidney medicine · 2023Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 9 institutions in 3 countries.
Funding
Abstract
BACKGROUND AND
objectivesCreatinine excretion rate (CER) indicates timed urine collection accuracy. Although equations to estimate CER exist, their bias and precision are untested and none simultaneously include age, sex, race, and weight. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Participants (n = 2466) from three kidney disease trials were randomly allocated into equation development (2/3) and internal validation (1/3) data sets. CER served as the dependent variable in linear regression to develop new equations. Their stability was assessed within the internal validation data set. Among 987 individuals from three additional studies the equations were externally validated and compared with existing equations.
resultsMean age was 46 years, 42% were women, and 9% were black. Age, sex, race, weight, and serum phosphorus improved model fit. Two equations were developed, with or without serum phosphorus. In external validation, the new equations showed little bias (mean difference [measured - estimated CER] -0.7% [95% confidence interval -2.5% to 1.0%] and 0.3% [95% confidence interval -2.6% to 3.1%], respectively) and moderate precision (estimated CER within 30% of measured CER among 79% [76% to 81%] and 81% [77% to 85%], respectively). Corresponding numbers within 15% were 51% [48% to 54%] and 54% [50% to 59%]). Compared with existing equations, the new equations had similar accuracy but showed less bias in individuals with high measured CER.
conclusionsCER can be estimated with commonly available variables with little bias and moderate precision, which may facilitate assessment of accuracy of timed urine collections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.