Trial reportAJNR. American journal of neuroradiology2011
Final cerebral infarct volume is predictable by MR imaging at 1 week.
Trial report in AJNR. American journal of neuroradiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04068961 (New Strategies of Genetic Study of Patients With Oculocutaneous Albinism), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
New Strategies of Genetic Study of Patients With Oculocutaneous Albinism
Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Perfusion-CT guided intravenous thrombolysis in patients with unknown-onset stroke: a randomized, double-blind, placebo-controlled, pilot feasibility trial.Neuroradiology · 2012Trial
- Hyperemia detection on arterial spin labeling is associated with final infarct volume in stroke post-endovascular therapy.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025Observational
- Late Lesion Growth following Endovascular Therapy: Is 24 h Too Early to Assess Acute Infarct Size Including the Effects of Secondary Injury?Cerebrovascular diseases (Basel, Switzerland) · 2025Article
- Follow-up infarct volume on fluid attenuated inversion recovery (FLAIR) imaging in distal medium vessel occlusions: the role of cerebral blood volume index.Journal of neurology · 2024Article
- The Effects of Vagus Nerve Stimulation on Animal Models of Stroke-Induced Injury: A Systematic Review.Biology · 2023Review
- Risk Factors of Hypoperfusion on MRI of Ischemic Stroke Patients Within 7 Days of Onset.Frontiers in neurology · 2021Article
- Machine learning identifies stroke features between species.Theranostics · 2021Article
- Infarct growth patterns may vary in acute stroke due to large vessel occlusion and recanalization with endovascular therapy.European radiology · 2020Article
- Matrix Metalloproteinase-9 Relationship With Infarct Growth and Hemorrhagic Transformation in the Era of Thrombectomy.Frontiers in neurology · 2020Article
- Active learning strategy and hybrid training for infarct segmentation on diffusion MRI with a U-shaped network.Journal of medical imaging (Bellingham, Wash.) · 2019Article
- A Machine Learning Approach for Classifying Ischemic Stroke Onset Time From Imaging.IEEE transactions on medical imaging · 2019Article
- Predicting ischemic stroke tissue fate using a deep convolutional neural network on source magnetic resonance perfusion images.Journal of medical imaging (Bellingham, Wash.) · 2019Article
- Impact of Ischemic Lesion Location on the mRS Score in Patients with Ischemic Stroke: A Voxel-Based Approach.AJNR. American journal of neuroradiology · 2018Article
- Optimizing image registration and infarct definition in stroke research.Annals of clinical and translational neurology · 2017Article
- Comparison of 3- and 20-Gradient Direction Diffusion-Weighted Imaging in a Clinical Subacute Cohort of Patients with Transient Ischemic Attack: Application of Standard Vendor Protocols for Lesion Detection and Final Infarct Size Projection.Frontiers in neurology · 2017Article
- Optimising MR perfusion imaging: comparison of different software-based approaches in acute ischaemic stroke.European radiology · 2016Article
- Article
- Final infarct volume estimation on 1-week follow-up MR imaging is feasible and is dependent on recanalization status.NeuroImage. Clinical · 2015Article
- Visual assessment of magnetic resonance imaging perfusion lesions in a large patient group.Clinical neuroradiology · 2012Article
- Magnetic Resonance Imaging Infarct Volume Correlates with Carotid Intima-Media Thickness and Plaque Echotexture in Ischemic Stroke.Journal of the West African College of SurgeonsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeStroke volume, an increasingly used end point in phase II trials, is considered stationary at least 30 days after the ictus. We investigated whether information conveyed by MR imaging measurements of the "final" infarct volume could be assessed as early as the subacute stage (days 3-6), rather than waiting for the chronic stage (days 30-45). MATERIALS AND
methodsNinety-five patients with middle cerebral artery stroke prospectively included in a multicenter study underwent MR imaging during the first 12 hours (MR imaging-1), between days 3 and 6 (MR imaging-2), and between days 30 and 45 (MR imaging-3). We first investigated the relationship between subacute (FLAIR-2) and chronic volumes (FLAIR-3), by using a linear regression model. We then tested the relationship between FLAIR volumes (either FLAIR-2 or FLAIR-3) and functional disability, measured by the mRS at the time of MR imaging-3, by using logistic regression. The performances of the models were assessed by using the AUC in ROC.
resultsA linear association between log FLAIR-2 and log FLAIR-3 volumes was observed. The proportion of FLAIR-3 variation, explained by FLAIR-2, was high (R(2) = 81%), without a covariate that improved this percentage. Both FLAIR-2 and FLAIR-3 were independent predictors of mRS (OR, 0.79 and 0.73; 95% CI, 0.64-0.97 and 0.56-0.96; P = .026 and .023). The performances of the models for the association between either FLAIR volume and mRS did not differ (AUC = 0.897 for FLAIR-2 and 0.888 for FLAIR-3).
conclusionsStroke damage may be assessed by a subacute volume because subacute volume predicts the "true" final volume and provides the same clinical prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.